Fig. 3

The growth, killing and kinetic curves of tavaborole coupled with AGAs. a Growth and killing curves of E. coli ATCC 25,922 and Y9633 treated with DMSO (Ctrl), tavaborole (Tava, 4 µg/ml), or tobramycin (TOB, 0.5 or 0.25 µg/ml) alone or in combination (Tava + TOB, 4 µg/ml + 0.5 µg/ml or 0.25 µg/ml). At intervals, the CFU/m of bacterial was determined. b PAE and PA-SME of Tava plus TOB (16 µg/ml + 4 µg/ml) in comparison with untreated control cultures and 1–4 × MIC of Tava or TOB alone against E. coli ATCC 25,922. All the trials were carried out three times