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Table 6 The effect of different combinations of LRJ and GE on wound diameter at days 1, 3, 7 10 in an animal model of MRSA skin infection

From: Evaluation of lyophilized royal jelly and garlic extract emulgels using a murine model infected with methicillin-resistant Staphylococcus aureus

Days post-induction Wound diameter (mm)
Group I Group II Group III Group IV Group V Group VI Group VII Group VIII
D1 0 19.7* ± 0.52 19.4* ± 0.83 19.4* ± 0.69 19.5* ± 0.39 19.5* ± 0.51 19.7* ± 0.45 19.4* ± 0.84
D3 0 17.6* ± 0.84 14.2*,# ± 0.67 13.1*,# ± 0.62 18.4* ± 0.87 16.5* ± 0.79 14.5*,# ± 0.69 14.0*,# ± 0.66
D7 0 14.0* ± 0.66 10.4*,# ± 0.49 8.1*,# ± 0.38 14.7* ± 0.7 11.4*,# ± 0.55 4.6*,#,† ± 0.22 3.1*,#,† ± 0.14
D10 0 9.9* ± 0.47 8.5*,# ± 0.41 2.3*,# ± 0.11 5.5*,# ± 0.26 5.1*,# ± 0.24 1.3*,#,† ± 0.06 0#,†
  1. Data are presented as Mean ± S.D. n = 6. Statistical analyses were carried out by Two-way ANOVA, followed by Tukey’s post-hoc test. *Significantly different from the corresponding group I (uninjured control) at P < 0.001. #Significantly different from the corresponding group II (injured, infected, untreated) at P < 0.001. Significantly different from the corresponding group IV (injured, uninfected, untreated) at P < 0.001. Group I: control, intact, non-infected, untreated, Group II: control, injured, infected, untreated, Group III: control, injured, infected, vehicle, Group IV: control, injured, non-infected, untreated, Group V: injured, infected, treated with Formula 1 (2% LRJ + 25% GE), Group VI: injured, infected, treated with Formula 2 (4% LRJ + 25% GE), Group VII: injured, infected, treated with Formula 3 (2% LRJ + 50% GE), Group VIII: injured, infected, treated with Formula 4 (4% LRJ + 50% GE)