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Table 6 The effect of different combinations of LRJ and GE on wound diameter at days 1, 3, 7 10 in an animal model of MRSA skin infection

From: Evaluation of lyophilized royal jelly and garlic extract emulgels using a murine model infected with methicillin-resistant Staphylococcus aureus

Days post-induction

Wound diameter (mm)

Group I

Group II

Group III

Group IV

Group V

Group VI

Group VII

Group VIII

D1

0

19.7* ± 0.52

19.4* ± 0.83

19.4* ± 0.69

19.5* ± 0.39

19.5* ± 0.51

19.7* ± 0.45

19.4* ± 0.84

D3

0

17.6* ± 0.84

14.2*,# ± 0.67

13.1*,# ± 0.62

18.4* ± 0.87

16.5* ± 0.79

14.5*,# ± 0.69

14.0*,# ± 0.66

D7

0

14.0* ± 0.66

10.4*,# ± 0.49

8.1*,# ± 0.38

14.7* ± 0.7

11.4*,# ± 0.55

4.6*,#,† ± 0.22

3.1*,#,† ± 0.14

D10

0

9.9* ± 0.47

8.5*,# ± 0.41

2.3*,# ± 0.11

5.5*,# ± 0.26

5.1*,# ± 0.24

1.3*,#,† ± 0.06

0#,†

  1. Data are presented as Mean ± S.D. n = 6. Statistical analyses were carried out by Two-way ANOVA, followed by Tukey’s post-hoc test. *Significantly different from the corresponding group I (uninjured control) at P < 0.001. #Significantly different from the corresponding group II (injured, infected, untreated) at P < 0.001. †Significantly different from the corresponding group IV (injured, uninfected, untreated) at P < 0.001. Group I: control, intact, non-infected, untreated, Group II: control, injured, infected, untreated, Group III: control, injured, infected, vehicle, Group IV: control, injured, non-infected, untreated, Group V: injured, infected, treated with Formula 1 (2% LRJ + 25% GE), Group VI: injured, infected, treated with Formula 2 (4% LRJ + 25% GE), Group VII: injured, infected, treated with Formula 3 (2% LRJ + 50% GE), Group VIII: injured, infected, treated with Formula 4 (4% LRJ + 50% GE)