Days post-induction | Wound diameter (mm) |
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Group I | Group II | Group III | Group IV | Group V | Group VI | Group VII | Group VIII |
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D1 | 0 | 19.7* ± 0.52 | 19.4* ± 0.83 | 19.4* ± 0.69 | 19.5* ± 0.39 | 19.5* ± 0.51 | 19.7* ± 0.45 | 19.4* ± 0.84 |
D3 | 0 | 17.6* ± 0.84 | 14.2*,# ± 0.67 | 13.1*,# ± 0.62 | 18.4* ± 0.87 | 16.5* ± 0.79 | 14.5*,# ± 0.69 | 14.0*,# ± 0.66 |
D7 | 0 | 14.0* ± 0.66 | 10.4*,# ± 0.49 | 8.1*,# ± 0.38 | 14.7* ± 0.7 | 11.4*,# ± 0.55 | 4.6*,#,† ± 0.22 | 3.1*,#,† ± 0.14 |
D10 | 0 | 9.9* ± 0.47 | 8.5*,# ± 0.41 | 2.3*,# ± 0.11 | 5.5*,# ± 0.26 | 5.1*,# ± 0.24 | 1.3*,#,† ± 0.06 | 0#,†|
- Data are presented as Mean ± S.D. n = 6. Statistical analyses were carried out by Two-way ANOVA, followed by Tukey’s post-hoc test. *Significantly different from the corresponding group I (uninjured control) at P < 0.001. #Significantly different from the corresponding group II (injured, infected, untreated) at P < 0.001. †Significantly different from the corresponding group IV (injured, uninfected, untreated) at P < 0.001. Group I: control, intact, non-infected, untreated, Group II: control, injured, infected, untreated, Group III: control, injured, infected, vehicle, Group IV: control, injured, non-infected, untreated, Group V: injured, infected, treated with Formula 1 (2% LRJ + 25% GE), Group VI: injured, infected, treated with Formula 2 (4% LRJ + 25% GE), Group VII: injured, infected, treated with Formula 3 (2% LRJ + 50% GE), Group VIII: injured, infected, treated with Formula 4 (4% LRJ + 50% GE)