A systematic study of the production of Monacolin K by solid state fermentation of Monascus ruber

AMB Express

Table 2 Box-Benhnken experiment results for significant factors

Source	Coefficient	Sum of squares	df	Mean squares	F-value	p-value
Model	14.40	117.92	9	13.10	95.79	< 0.0001**
A	0.85	5.73	1	5.73	41.88	0.0003**
B	− 0.26	0.53	1	0.53	3.88	0.0896
C	1.50	17.97	1	17.97	131.38	< 0.0001**
AB	0.82	2.72	1	2.72	19.90	0.0029**
AC	0.55	1.22	1	1.22	8.93	0.0203*
BC	0.62	1.54	1	1.54	11.24	0.0122*
A²	− 3.26	44.64	1	44.64	326.39	< 0.0001**
B²	− 0.88	3.25	1	3.25	23.77	0.0018**
C²	− 2.80	33.04	1	33.04	241.55	< 0.0001**
Residual		0.96	7	0.14
Lack of fit		0.49	3	0.16	1.39	0.3673
Pure error		0.47	4	0.12
Core total		118.88	16