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Table 2 The binding affinity of DENV-LPs towards heparin

From: Humoral immune response induced with dengue virus-like particles serotypes 1 and 4 produced in silkworm

Protein KD (nM) Ka (M–1) N ΔG (kcal mol–1) Ligand Host Method Refs.
DENV-LP/1CprME 235.2 4.44 × 106 0.88 – 8.92 Heparin B. mori ITC This study
DENV-LP/1prME 952.4 1.05 × 106 0.98 – 9.28 Heparin B. mori ITC This study
DENV-LP/4CprME 197.6 5.06 × 106 1.14 – 8.99 Heparin B. mori ITC This study
DENV-LP/4prME 819.7 1.22 × 106 0.58 – 8.85 Heparin B. mori ITC This study
DENV-2 E protein 5.0 O-sulfated heparin E. coli SPR Marks et al. (2001)
DENV-2 E protein 5.0 N- and O-sulfated heparin E. coli SPR Marks et al. (2001
DENV-2 E protein 15.0 Heparin COS-7 ITC Chen et al. (1997)
ZIKV-E 433.0 Heparin E. coli SPR Kim et al. (2017)