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Table 3 The differentially expressed genes involved in metabolism by comparative transcriptome analysis of strains F1-P (A), F1-A (B), F2-A (C)

From: Modular control of multiple pathways of Corynebacterium glutamicum for 5-aminolevulinic acid production

Gene ID

Gene name

Annotaion

Log2Fold change

BVsA

CVsA

CVsB

Genes belonging to the GS/GDH/GOGAT regulon

 C629_RS01290

gltB

Glutamate synthase large subunit

− 2.29

 + 5.53

 + 7.77

 C629_RS01295

gltD

Glutamate synthase subunit beta

 + 0.10

 + 7.01

 + 6.86

 C629_RS10845

glnA

Type I glutamate–ammonia ligase

− 1.98

 + 1.73

 + 3.65

 C629_RS14595

gdhA

Glu dehydrogenase

 + 1.48

− 1.82

− 0.28

Genes belonging to the C5 regulon

 C629_RS07300

gltX

ABC transporter substrate-binding protein

− 1.58

− 0.42

 + 1.11

 C629_RS02480

hemA

Glutamyl-tRNA reductase

− 2.87

− 3.08

− 0.26

 C629_RS02585

hemL

Glutamate-1-semialdehyde

− 0.95

− 0.78

 + 0.11

Genes belonging to the TCA regulon

 C629_RS04175

icd

NADP-dependent isocitrate dehydrogenase

 + 1.22

 + 2.27

 + 0.99

 C629_RS04310

lpdA

NAD(P)H-quinone dehydrogenase

 + 0.48

 + 0.69

 + 0.15

 C629_RS12810

sucC

ADP-forming succinate–CoA ligase subunit beta

− 0.85

− 0.92

− 0.13

 C629_RS12805

sucD

Succinate–CoA ligase subunit alpha

− 0.56

− 1.74

− 1.24

 C629_RS02275

sdhB

Succinate dehydrogenase/fumarate reductase iron-sulfur subunit

− 2.04

− 0.77

 + 1.22

 C629_RS02270

sdhA

Fumarate reductase/succinate dehydrogenase flavoprotein subunit

− 2.21

− 0.95

 + 1.21

 C629_RS02265

sdhCD

Succinate dehydrogenase cytochrome b subunit

− 2.91

− 1.77

 + 1.08

Genes belonging to the Glycolysis

 C629_RS05175

pgi

Phosphoglucomutase

 + 1.39

 + 1.31

− 0.13

 C629_RS02375

gpmA

Phosphoglyceromutase

 + 3.77

 + 3.61

− 0.21

 C629_RS08700

pgk

Phosphoglycerate kinase

 + 2.07

 + 1.42

− 0.70

Genes belonging to the Heme regulon

 C629_RS02555

hemB

Porphobilinogen synthase

− 0.14

− 1.494

− 1.364

 C629_RS02485

hemC

Hydroxymethylbilane synthase

− 1.50

− 1.54

− 0.09

 C629_RS02545

hemD

Bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase

− 1.66

− 1.36

 + 0.24

 C629_RS02575

hemE

Uroporphyrinogen decarboxylase

− 0.54

− 0.69

− 0.20

 C629_RS11225

hemN

Coproporphyrinogen III oxidase

 +  0.99

 + 0.31

− 0.73

 C629_RS02580

hemY

Protoporphyrinogen oxidase

− 1.16

− 1.27

− 0.16

 C629_RS09295

hemQ

Chlorite dismutase family protein

− 1.04

− 0.38

 + 0.61

 C629_RS08570

hemH

Ferrochelatase

− 0.84

− 0.44

 + 0.34

Two-component system

 C629_RS14495

hrrA

Two-component system, response regulator

 + 3.48

 + 3.57

 + 0.03

 C629_RS14500

hrrS

Two-component system, signal transduction histidine kinase

 + 4.06

 + 4.91

 + 0.80

  1. A: C. glutamicum/pXMJ19 (F1-P); B: C. glutamicum/pXMJ19-hemAC4 (F1-A); C:C. glutamicumgdhA/ pXMJ19-hemAC4 (F2-A)