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Table 3 The differentially expressed genes involved in metabolism by comparative transcriptome analysis of strains F1-P (A), F1-A (B), F2-A (C)

From: Modular control of multiple pathways of Corynebacterium glutamicum for 5-aminolevulinic acid production

Gene ID Gene name Annotaion Log2Fold change
BVsA CVsA CVsB
Genes belonging to the GS/GDH/GOGAT regulon
 C629_RS01290 gltB Glutamate synthase large subunit − 2.29  + 5.53  + 7.77
 C629_RS01295 gltD Glutamate synthase subunit beta  + 0.10  + 7.01  + 6.86
 C629_RS10845 glnA Type I glutamate–ammonia ligase − 1.98  + 1.73  + 3.65
 C629_RS14595 gdhA Glu dehydrogenase  + 1.48 − 1.82 − 0.28
Genes belonging to the C5 regulon
 C629_RS07300 gltX ABC transporter substrate-binding protein − 1.58 − 0.42  + 1.11
 C629_RS02480 hemA Glutamyl-tRNA reductase − 2.87 − 3.08 − 0.26
 C629_RS02585 hemL Glutamate-1-semialdehyde − 0.95 − 0.78  + 0.11
Genes belonging to the TCA regulon
 C629_RS04175 icd NADP-dependent isocitrate dehydrogenase  + 1.22  + 2.27  + 0.99
 C629_RS04310 lpdA NAD(P)H-quinone dehydrogenase  + 0.48  + 0.69  + 0.15
 C629_RS12810 sucC ADP-forming succinate–CoA ligase subunit beta − 0.85 − 0.92 − 0.13
 C629_RS12805 sucD Succinate–CoA ligase subunit alpha − 0.56 − 1.74 − 1.24
 C629_RS02275 sdhB Succinate dehydrogenase/fumarate reductase iron-sulfur subunit − 2.04 − 0.77  + 1.22
 C629_RS02270 sdhA Fumarate reductase/succinate dehydrogenase flavoprotein subunit − 2.21 − 0.95  + 1.21
 C629_RS02265 sdhCD Succinate dehydrogenase cytochrome b subunit − 2.91 − 1.77  + 1.08
Genes belonging to the Glycolysis
 C629_RS05175 pgi Phosphoglucomutase  + 1.39  + 1.31 − 0.13
 C629_RS02375 gpmA Phosphoglyceromutase  + 3.77  + 3.61 − 0.21
 C629_RS08700 pgk Phosphoglycerate kinase  + 2.07  + 1.42 − 0.70
Genes belonging to the Heme regulon
 C629_RS02555 hemB Porphobilinogen synthase − 0.14 − 1.494 − 1.364
 C629_RS02485 hemC Hydroxymethylbilane synthase − 1.50 − 1.54 − 0.09
 C629_RS02545 hemD Bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase − 1.66 − 1.36  + 0.24
 C629_RS02575 hemE Uroporphyrinogen decarboxylase − 0.54 − 0.69 − 0.20
 C629_RS11225 hemN Coproporphyrinogen III oxidase  +  0.99  + 0.31 − 0.73
 C629_RS02580 hemY Protoporphyrinogen oxidase − 1.16 − 1.27 − 0.16
 C629_RS09295 hemQ Chlorite dismutase family protein − 1.04 − 0.38  + 0.61
 C629_RS08570 hemH Ferrochelatase − 0.84 − 0.44  + 0.34
Two-component system
 C629_RS14495 hrrA Two-component system, response regulator  + 3.48  + 3.57  + 0.03
 C629_RS14500 hrrS Two-component system, signal transduction histidine kinase  + 4.06  + 4.91  + 0.80
  1. A: C. glutamicum/pXMJ19 (F1-P); B: C. glutamicum/pXMJ19-hemAC4 (F1-A); C:C. glutamicumgdhA/ pXMJ19-hemAC4 (F2-A)