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Table 2 Summary of genes that contribute to improved OMV production in bacteria

From: Enhancement of membrane vesicle production by disrupting the degP gene in Meiothermus ruber H328

Gene Function Meiothermus ruber Escherichia coli Salmonella enterica Helicobacter pyroli Pseudomonas aeruginosa References
degP Periplasmic
serine protease
× Schwechheimer and Kuehn (2013)
tolRA OM integrity × Turner et al. (2015)
Bernadac et al. (1998)
Daleke-Schermerhorn et al. (2014)
nlpI OM lipoprotein × × × McBroom et al. (2006)
Nevermann et al. (2019)
gmhB D-glycero-β-D-manno-heptose-1,7-bisphosphate 7-phosphatase × Kulp et al. (2015)
rfaD ADP-L-glycero-D-mannoheptose 6-epimerase × Kulp et al. (2015)
rfaE Heptose 7-phosphate
kinase/heptose 1-phosphate adenyltransferase
× Nevermann et al. (2019)
vacJ/yrbB ABC transport system IM phospholipid transport system protein × × × Roier et al. (2016)
  1. OM outer membrane, IM inner membrane