An endophytic Schizophyllum commune Fr. exhibits in-vitro and in-vivo antidiabetic activity in streptozotocin induced diabetic rats

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Table 3 Effect of S. commune extract on oxidative stress parameters in STZ induced diabetic rats

Groups	GSH Kidney (µmol/mg protein)	GSH Liver (µmol/mg protein)	TBARS Kidney (nmol/mg protein)	TBARS Liver (nmol/mg protein)	SAG Kidney (pmol/min/mg tissue)	SAG Liver (pmol/min/mg tissue)
NC	11.01 ± 1.620	9.24 ± 1.088	0.398 ± 0.103	0.624 ± 0.128	5.04 ± 0.823	4.78 ± 1.304
DC	4.720 ± 0.486^a	4.018 ± 0.623^a	1.766 ± 0.296^a	1.628 ± 0.378^a	18.612 ± 1.868^a	17.512 ± 1.571^a
PC	11.892 ± 1.880^b	8.168 ± 1.864^b	0.532 ± 0.127^b	0.602 ± 0.057^b	6.19 ± 0.862^b	7.228 ± 0.640^a,b
SC50	6.862 ± 0.768^a	5.092 ± 0.690^a	1.118 ± 0.103^a,b	1.038 ± 0.082^a,b	13.104 ± 1.159^a,b	12.832 ± 1.007^a,b
SC100	9.556 ± 1.032^b,c	8.104 ± 1.647^b,c	0.604 ± 0.105^b,c	0.732 ± 0.084^b	10.21 ± 1.239^a,b,c	10.216 ± 0.746^a,bc

Data are expressed as mean ± S.D. (n = 5). NC: normal healthy control; DC: diabetic control; PC: positive control (STZ induced diabetic rats treated with reference drug acarbose (60 mg/kg body weight)); SC50 and SC100: STZ induced diabetic rats treated with S. commune extract (50 and 100 mg/kg body weight respectively)
^aP < 0.05 Different control groups when compared with normal group
^bP < 0.05 Diabetic control group when compared with other treated groups
^cP < 0.05 S. commune extract treated groups when compared with each other