Bactericidal activity of Myrrh extracts and two dosage forms against standard bacterial strains and multidrug-resistant clinical isolates with GC/MS profiling

AMB Express

Table 6 In-vitro cytotoxic activity of Myrrh hexane extract and essential oil

Test	Liver cancer cell line (Hep G2)	Selectivity index (SI)	Breast tumor cell line (MCF-7)	Selectivity index	Colon cancer cell line (HCT-116)	Selectivity index (SI)
Test	IC₅₀ (μg/ml)	Selectivity index (SI)	IC₅₀ (μg/ml)	Selectivity index	IC₅₀ (μg/ml)	Selectivity index (SI)
Hexane extract	30.33 ± 0.99^aB	3.50	16.32 ± 0.65^aB	3.66	26.28 ± 0.78^aB	3.25
Essential oil	41.52 ± 1.11^bB	2.85	10.93 ± 0.32^bB	3.47	19.71 ± 0.92^bB	3.69
Doxorubicin	9.79 ± 0.62^A		4.25 ± 0.44^A		7.22 ± 0.17^A

Values are ± SEM (n = 3), means followed by different letters in same column denote significant difference at p < 0.05, paired-t-test. Lowercase letters compare means of Myrrh hexane extract and essential oil, uppercase letters compare means of sample with the standard doxorubicin
Selectivity index was calculated as the ratio of the IC₅₀ values on normal hamster lung fibroblasts (V79) to those in the tested cancer cell lines. SI > 3 indicates a promising activity