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AMB Express
Fig. 4 | AMB Express

Fig. 4

From: NADPH biosensor-based identification of an alcohol dehydrogenase variant with improved catalytic properties caused by a single charge reversal at the protein surface

Fig. 4

Crystal structure of the LbADHWT monomer and the homotetramer in complex with the substrate acetophenone and the cofactor NADPH (Schlieben et al. 2005) (a) and modelled structure of LbADHK71E (b). In the tetrameric structure, the Mg2+ ions needed for structure stabilization are shown as light green spheres. The amino acids at position 71 are shown as sticks and marked with a black circle. The residues Asn113, Ser142, Tyr155, Lys159 involved in the catalytic mechanism are shown in red as sticks in the monomer. The images were generated with the software PyMOL 2.2.0 (PDB code 1ZK4)

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