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Table 2 Combinational effects of eugenol and antimicrobial drugs on pre-formed C. albicans and S. mutans MTCC497 single and mixed biofilms

From: Synergistic interaction of eugenol and antimicrobial drugs in eradication of single and mixed biofilms of Candida albicans and Streptococcus mutans

Test strains Test combinations (concentration)
1. CAJ-01 EUG/FLZ (µg/mL) EUG/AMB (µg/mL)
EUG FLZ EUG AMB
Alone MIC 400 512 400 256
Combination MIC 50 64 100 128
FICI 0.250 0.625
Type of interaction Synergy Indifferent
2. CAJ-12 EUG/FLZ (µg/mL) EUG/AMB (µg/mL)
EUG FLZ EUG AMB
Alone MIC 200 1024 200 32
Combination MIC 6.25 128 25 16
FICI 0.156 0.625
Type of interaction Synergy Indifferent
3. S. mutans MTCC497 EUG/AZI (µg/mL)  
EUG AZI   
Alone MIC 200 512   
Combination MIC 12.5 64   
FICI 0.187   
Type of interaction Synergy   
4. CAJ-01 plus S. mutans MTCC497 EUG/FLZ (µg/mL) EUG/AZI (µg/mL)
EUG FLZ EUG AZI
Alone MIC 800 1024 800 1024
Combination MIC 25 128 12.5 128
FICI 0.156 0.140
Type of interaction Synergy Synergy
5. CAJ-12 plus S. mutans MTCC497 EUG/FLZ (µg/mL) EUG/AZI (µg/mL)
EUG FLZ EUG AZI
Alone MIC 200 2048 200 1024
Combination MIC 12.5 256 3.12 128
FICI 0.187 0.140
Type of interaction Synergy Synergy
  1. EUG eugenol, FLC fluconaole, AMB amphotericin B, AZI azithjromycin