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Table 4 Total polyphenol content in solutions of test compounds applied to the skin, acceptor fluid solutions obtained after 24 h of collection, and solutions obtained after skin extraction

From: Enhancement of the antioxidant and skin permeation properties of eugenol by the esterification of eugenol to new derivatives

Compound

Antioxidant activity (Folin–Ciocalteu method):

Solution applied to the skin

Acceptor fluid after 24 h of penetration

Solution after skin extraction

mmol gallic acid/dm3

Eugenol*

3.84 ± 0.05a

0.27 ± 0.01a

0.41 ± 0.03b

EDChA *

3.27 ± 0.10b

0.22 ± 0.01b

0.58 ± 0.04a

ETChA*

3.35 ± 0.06b

0.25 ± 0.01ab

0.55 ± 0.01a

DChAA

No activity

No activity

No activity

TChAA

No activity

No activity

No activity

  1. * Mean ± S.D. (n = 3), different letters - values are significantly different, mass substance in the acceptor fluid (P < 0.001)