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Table 1 Antimicrobial activity of products 3a to 3f, educts 2a to 2c and comparable data from previous research (educts 2A to 2C and products 3A to 3C)

From: Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid

Strain Amount n [µmol]
2a 3a 3b 2A (AM) c 3A (1a + AM) c
0.019 0.1 0.19 0.019 0.1 0.19 0.019 0.1 0.19 0.019 0.1 0.19 0.019 0.1 0.19
Staphylococcus aureus ATCC 6538 ra r r 12b 18 22 r 24 30 36 42 44 26 30 34
S. aureus Norddeutscher Stamm r r r r 16 18 r r 16 r 12 14 r 10 14
S. aureus 315 r r r r r r r r r 8 14 16 r 8 12
S. epidermidis 99,847 r r r r r r r r r 20 24 26 14 20 22
Strain Amount n [µmol]
2b 3c 3d 2B (CD) d 3B (1a + CD) d
0.019 0.1 0.19 0.019 0.1 0.19 0.019 0.1 0.19 0.019 0.1 0.19 0.019 0.1 0.19
S. aureus ATCC 6538 r r r r 14 18 r r 10 32 38 40 20 28 30
S. aureus Norddeutscher Stamm r r r r 20 24 r r r r r 10 r 16 18
S. aureus 315 r r r r r r r r r r r 8 r 10 16
S. epidermidis 99,847 r r r r r 22 r r 14 20 24 26 r 10 16
Strain Amount n [µmol]
2c 3e 3f 2B (CD) d 3C (1b + CD) d
0.019 0.1 0.19 0.019 0.1 0.19 0.019 0.1 0.19 0.019 0.1 0.19 0.019 0.1 0.19
S. aureus ATCC 6538 r r r r 18 22 r 14 30 32 38 40 18 26 30
S. aureus Norddeutscher Stamm r r r r 20 22 r r r r r 10 r 10 14
S. aureus 315 r r r r r r r r r r r 8 r r 12
S. epidermidis 99,847 r r r r r 24 r r r 20 24 26 r 14 20
  1. a Resistant (no zone of inhibition)
  2. b Zones of inhibition (mm)
  3. c Educt 2A and product 3A are described previously (Mikolasch et al. 2006); AM amoxicillin
  4. d Educt 2B and products 3B, 3C are described previously (Mikolasch et al. 2007); CD cefadroxil
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