TY - JOUR AU - Mikolasch, Annett AU - Hammer, Elke AU - Witt, Sabine AU - Lindequist, Ulrike PY - 2020 DA - 2020/10/02 TI - Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid JO - AMB Express SP - 177 VL - 10 IS - 1 AB - Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of 6-aminopenicillanic, 7-aminocephalosporanic, and 7-aminodesacetoxycephalosporanic acid with 2,5-dihydroxybenzoic acid derivatives to form new penicillin and cephalosporin structures, respectively. The heteromolecular hybrid dimers are formed by nuclear amination of the p-hydroquinones with the primary amines and inhibited in vitro the growth of Staphylococcus species, including some multidrug-resistant strains. SN - 2191-0855 UR - https://doi.org/10.1186/s13568-020-01117-0 DO - 10.1186/s13568-020-01117-0 ID - Mikolasch2020 ER -