Fig. 4
From: Identification of the natural product berberine as an antiviral drug
Effect of berberine on the secondary structure of 6-HB structure by CD spectroscopy. a The secondary structure of 6-HB in the absence of berberine displayed a typical helical conformation, while lost α-helical conformation in the presence of berberine. N36 and C34 served as negative controls, C34 + N36 served as a positive control. The molar ratio of N36 and C34 in a sample was 1:1. b Model of interaction of berberine with NHR and CHR helices of gp41. NHR and CHR helices were indicated in light green and orange, respectively. Berberine was abbreviated to acronyms BBR