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Table 2 Effects of garcinol on hemodynamic markers and cardiac function in isoproterenol-treated rats

From: Cardioprotective effects of garcinol following myocardial infarction in rats with isoproterenol-induced heart failure

Hemodynamic markers

Sham

Control

Low-dose

High-dose

Digitalis

SBP (mmHg)

99.2 ± 10.1

72.5 ± 6.5*

77.8 ± 5.1

92.4 ± 9.1#

96.5 ± 8.2##

DBP (mmHg)

59.1 ± 5.2

44.3 ± 4.1*

46.2 ± 4.2

52.5 ± 4.1#

54.1 ± 4.3#

HR (beat/min)

358.2 ± 16.2

296.1 ± 12.2*

317.2 ± 14.2

351.3 ± 14.1#

355.2 ± 15.4##

+LV dp/dtmax (mmHg/s)

7226.5 ± 681.3

3145.1 ± 273.2***

3818.2 ± 319.2#

6915.2 ± 510.2##

6716.3 ± 562.5###

−LV dp/dtmax (mmHg/s)

5581.5 ± 511.3

2811.4 ± 191.2***

3443.1 ± 241.5#

5412.2 ± 291.3##

5113.2 ± 325.6###

LVSP

126.5 ± 11.5

77.3 ± 5.1*

91.4 ± 4.6#

119.8 ± 7.1##

117.2 ± 8.1###

LVEF

75.3 ± 5.1

50.7 ± 4.1*

59.4 ± 3.8

72.2 ± 4.8#

69.5 ± 4.2#

  1. ±LV dp/dtmax: Maximal rates of increase and decrease of left-ventricle pressure development. Data are expressed as mean ± SEM. n= 6 in each group
  2. HR Heart rate, DBP Diastolic blood pressure, SBP Systolic blood pressure, LVSP Left ventricular systolic pressure, LVEF Left ventricular ejection fraction
  3. *P< 0.05 vs group I
  4. #P< 0.05
  5. ##P< 0.01
  6. ###P< 0.001 vs group II