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Table 2 Effects of garcinol on hemodynamic markers and cardiac function in isoproterenol-treated rats

From: Cardioprotective effects of garcinol following myocardial infarction in rats with isoproterenol-induced heart failure

Hemodynamic markers Sham Control Low-dose High-dose Digitalis
SBP (mmHg) 99.2 ± 10.1 72.5 ± 6.5* 77.8 ± 5.1 92.4 ± 9.1# 96.5 ± 8.2##
DBP (mmHg) 59.1 ± 5.2 44.3 ± 4.1* 46.2 ± 4.2 52.5 ± 4.1# 54.1 ± 4.3#
HR (beat/min) 358.2 ± 16.2 296.1 ± 12.2* 317.2 ± 14.2 351.3 ± 14.1# 355.2 ± 15.4##
+LV dp/dtmax (mmHg/s) 7226.5 ± 681.3 3145.1 ± 273.2*** 3818.2 ± 319.2# 6915.2 ± 510.2## 6716.3 ± 562.5###
−LV dp/dtmax (mmHg/s) 5581.5 ± 511.3 2811.4 ± 191.2*** 3443.1 ± 241.5# 5412.2 ± 291.3## 5113.2 ± 325.6###
LVSP 126.5 ± 11.5 77.3 ± 5.1* 91.4 ± 4.6# 119.8 ± 7.1## 117.2 ± 8.1###
LVEF 75.3 ± 5.1 50.7 ± 4.1* 59.4 ± 3.8 72.2 ± 4.8# 69.5 ± 4.2#
  1. ±LV dp/dtmax: Maximal rates of increase and decrease of left-ventricle pressure development. Data are expressed as mean ± SEM. n= 6 in each group
  2. HR Heart rate, DBP Diastolic blood pressure, SBP Systolic blood pressure, LVSP Left ventricular systolic pressure, LVEF Left ventricular ejection fraction
  3. *P< 0.05 vs group I
  4. #P< 0.05
  5. ##P< 0.01
  6. ###P< 0.001 vs group II