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Table 5 Effects of nisin/glabridin, nisin/licoricidin, and nisin/licochalcone A on the viability of oral epithelial cells, gingival fibroblasts, and stem cells of the apical papilla (SCAP) after a 2-h contact

From: Biocompatible combinations of nisin and licorice polyphenols exert synergistic bactericidal effects against Enterococcus faecalis and inhibit NF-κB activation in monocytes

Mixtures

Cell viability (%)

Oral epithelial cells

Gingival fibroblasts

SCAP

None (control)

100

100

111.8 ± 9.5

Nisin (25 µg/mL)/Glabridin (50 µg/mL)

71.5 ± 9.2*

82.5 ± 5*

5.0 ± 2.1*

Nisin (12.5 µg/mL)/Glabridin (25 µg/mL)

115.0 ± 19.4

148.2 ± 11.0

122.4 ± 3.6

Nisin (25 µg/mL)/Licoricidin (12.5 µg/mL)

134.3 ± 2.4

116.0 ± 2.5

107.2 ± 6.0

Nisin (12.5 µg/mL)/Licoricidin (6.25 µg/mL)

131.1 ± 3.6

113.5 ± 5.4

104.2 ± 8.4

Nisin (25 µg/mL)/Licochalcone A (25 µg/mL)

139.3 ± 4.2

99.8 ± 14.1

116.9 ± 6.7

Nisin (12.5 µg/mL)/Licochalcone A (12.5 µg/mL)

137.0 ± 5.6

104.0 ± 18.3

114.4 ± 4.5

  1. *Significant decrease (p < 0.01) compared to untreated control cell