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Table 5 Effects of nisin/glabridin, nisin/licoricidin, and nisin/licochalcone A on the viability of oral epithelial cells, gingival fibroblasts, and stem cells of the apical papilla (SCAP) after a 2-h contact

From: Biocompatible combinations of nisin and licorice polyphenols exert synergistic bactericidal effects against Enterococcus faecalis and inhibit NF-κB activation in monocytes

Mixtures Cell viability (%)
Oral epithelial cells Gingival fibroblasts SCAP
None (control) 100 100 111.8 ± 9.5
Nisin (25 µg/mL)/Glabridin (50 µg/mL) 71.5 ± 9.2* 82.5 ± 5* 5.0 ± 2.1*
Nisin (12.5 µg/mL)/Glabridin (25 µg/mL) 115.0 ± 19.4 148.2 ± 11.0 122.4 ± 3.6
Nisin (25 µg/mL)/Licoricidin (12.5 µg/mL) 134.3 ± 2.4 116.0 ± 2.5 107.2 ± 6.0
Nisin (12.5 µg/mL)/Licoricidin (6.25 µg/mL) 131.1 ± 3.6 113.5 ± 5.4 104.2 ± 8.4
Nisin (25 µg/mL)/Licochalcone A (25 µg/mL) 139.3 ± 4.2 99.8 ± 14.1 116.9 ± 6.7
Nisin (12.5 µg/mL)/Licochalcone A (12.5 µg/mL) 137.0 ± 5.6 104.0 ± 18.3 114.4 ± 4.5
  1. *Significant decrease (p < 0.01) compared to untreated control cell