Group | Group name | Number of animals | Immunization | Dose | Challenge |
---|---|---|---|---|---|
1 | PBSC1 | 6 | PBS | 100 μg/0.2 mL/per mouse | APP1 |
2 | PBSC5 | 6 | PBS | 100 μg/0.2 mL/per mouse | APP5b |
3 | RTAC1 | 6 | RTA | 0.2 mL/per mouse | APP1 |
4 | RTAC5 | 6 | RTA | 0.2 mL/per mouse | APP5b |
5 | IB1-C1 | 6 | inactivated APP1 | 108 CFU of APP1/0.2 mL/per mouse | APP1 |
6 | IB1-C5 | 6 | inactivated APP1 | 108 CFU of APP1/0.2 mL/per mouse | APP5b |
7 | IB5-C1 | 6 | inactivated APP5b | 108 CFU of APP5b/0.2 mL/per mouse | APP1 |
8 | IB5-C5 | 6 | inactivated APP5b | 108 CFU of APP5b/0.2 mL/per mouse | APP5b |
9 | RTAIB1 + C1 | 6 | RTA +inactivated APP1 | 100 μg of RTA + 108 CFU of APP1/0.2 mL/per mouse | APP1 |
10 | RTAIB1 + C5 | 6 | RTA +inactivated APP1 | 100 μg of RTA + 108 CFU of APP1/0.2 mL/per mouse | APP5b |
11 | RTAIB5 + C1 | 6 | RTA +inactivated APP5b | 100 μg of RTA + 108 CFU of APP5b/0.2 mL/per mouse | APP1 |
12 | RTAIB5 + C5 | 6 | RTA +inactivated APP5b | 100 μg of RTA + 108 CFU of APP5b/0.2 mL/per mouse | APP5b |