Fig. 6

Detection of the clinical symptoms, weight changes, lung indexes and survival rates of mice. a1, a2 The clinical symptoms of each mouse were observed and scored at 0, 6, 12, 24, 48 and 72 h after challenge. b1, b2 The weight of each mouse was recorded at 0, 6, 12, 24, 48, and 72 h after challenge, and the weight changes of the mice were calculated (weight changes = the initial weight- the real-time weight); * represents the RTA IB1 + C1 group or the RTA IB5 + C1 group compared with the PBSC1 group and was statistically significant; # represents the RTA IB1 + C5 group or the RTA IB5 + C5 group compared with the PBSC5 group and was statistically significant. * or #, P < 0.05; ** or ##, P < 0.01. c The body weight and the lung weight of the mice were recorded at 72 h after challenge, and the lung indexes of the mice were calculated. d. The survival rates of the mice immunized with PBS, RTA protein combined with inactivated APP1 or APP5b at 0, 14, and 28 d and challenged with APP1 and APP5b separately at 35 d. The mice were observed for 3 d to record the survival rate