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AMB Express
Fig. 2 | AMB Express

Fig. 2

From: The role of autophagy in the cytotoxicity induced by trastuzumab emtansine (T-DM1) in HER2-positive breast cancer cells

Fig. 2

Autophagy was triggered by T-DM1 in SK-BR-3 and BT-474 cells. SK-BR-3 cells were treated with 20 ng/mL of T-DM1 and BT-474 cells were cultured with 500 ng/mL of T-DM1 for 3 days. a Representative electron micrographs of T-DM1-treated SK-BR-3 as well as BT-474 cells. b, c LC3-I/II expression levels were examined after T-DM1 treatment. Relative expression levels of LC3-II/GAPDH were presented in bar charts. d, e Accumulations of autophagosomes in breast cancer cells were observed with Cyto-ID staining by confocal microscopy

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