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AMB Express
Fig. 1 | AMB Express

Fig. 1

From: The role of autophagy in the cytotoxicity induced by trastuzumab emtansine (T-DM1) in HER2-positive breast cancer cells

Fig. 1

T-DM1 induced apoptosis and Caspase-3/7 activation in SK-BR-3 and BT-474 cells. a, b Cells were incubated with T-DM1 for 2 days, and then examined by flow cytometry. Percentages of Annexin V/PI-positive cells were shown in bar charts. c Cells were cultured with different concentrations of T-DM1 for 2 days and caspase-3/7 activation was analyzed by commercial kits. d SK-BR-3 cells (20 ng/mL of T-DM1) and BT-474 cells (250 ng/mL of T-DM1) were exposed to 20 μM of Z-VAD-fmk for 2 days and Caspase-3/7 activation of both two cells was detected

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