Table 6 ELD50 and ELD50 of the progeny strains
Immune status | Tissue | Strains | Mutations | EID50 | ELD50 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
HA | NA | PB2 | NP | NS1 | M1 | |||||
Immunized | Trachea | V1 | K131R, A198T, L234Q | Amino acids 67–76 deletion | R318K, R355K | – | – | – | 6.9 | 0 |
Immunized | Lung | V2 | K131R, A168T, A198T, L234Q | Amino acids 67–76 deletion | R318K | – | – | – | 7 | 0 |
Immunized | Trachea | V3 | K131R, N201D, A198T, L234Q | Amino acids 67–76 deletion | – | – | – | – | 7.2 | 0 |
Immunized | Lung | V4 | K131R, A198T, L234Q | Amino acids 67–76 deletion | R318K, R355K | – | – | – | 7 | 0 |
Immunized | Lung | V5 | K131R, A198T, L234Q | Amino acids 67–76 deletion | – | – | – | – | 7 | 0 |
Nonimmunized | Trachea | N1 | A198V, M224K, Q234L, L281F, N285D | – | R318K | V186I, L466I | L77I | F62L | 9.5 | 7.4 |
Nonimmunized | Trachea | N2 | A198V, M224K, Q234L, N285D | – | R318K | V186I, L466I | L77I | F62L | 9.6 | 7.3 |
Nonimmunized | Lung | N3 | A198V, M224K, Q234L, L281F, N285D | – | R318K | V186I, L466I | L77I | F62L | 9.1 | 7.2 |
Nonimmunized | Lung | N4 | E114K, A198V, M224K, Q234L, L281F, N285D | – | R318K | V186I, L466I | L77I | F62L | 9.8 | 7.5 |
Nonimmunized | Trachea | N5 | A198V, M224K, Q234L, L281F, N285D | – | R318K | V186I, L466I | L77I | F62L | 9.4 | 7.4 |