Fig. 2
MG1363-pMG36e-GLP-1 reversed the pathological changes induced by LPS. a MG1363-pMG36e-GLP-1 reduced the expression of TLR4, p-IκBαand p-p65 on mouse brain induced by LPS (IHC staining of hippocampus). b MG1363-pMG36e-GLP-1 decreased the expression of p-AKT/AKT, p-GSK3β/GSK3βand β-catenin on mouse brain induced by LPS (IHC staining of hippocampus). c MG1363-pMG36e-GLP-1 alleviated the Aβdeposition on mouse brain induced by LPS (IF staining of hippocampus). C, control group (n = 8); AD, LPS group (n = 5); AD-G, LPS + 109 CFU MG1363-pMG36e-GLP-1 group (n = 5); PD, MPTP group (n = 8); PD-G, MPTP + 109 CFU MG1363-pMG36e-GLP-1 group (n = 8). Data are presented as mean ± SD. *p < 0.05