Fig. 5
From: Bacterial delivery of the anti-tumor azurin-like protein Laz to glioblastoma cells
Cytotoxic effect of the S. typhimurium VNP20009 expressing Laz (VNP-Laz) on tumor cells in vitro. Monolayers glioblastoma cell line U-373 (carrying a mutated p53) were co-cultured with VNP alone, or VNP-Laz using the same bacterial densities mentioned above, under hypoxic conditions for 24 h. Apoptosis was assessed as mentioned above. All data are shown as mean ± s.e.m and represent data from three independent experiments n = 3. *P < 0.0001 with respect to the control groups at the same concentration