Table 2 Regulatory pathways and gene modifications by Lactobacillus johnsonii BS15 decreased liver inflammation
Pathway | Genes |
|---|---|
Cytokine-cytokine receptor interaction | CCR2; CX3CR1; IFNGR1; IL18; IL1B; IL2RA; IL2RG; TNFRSF1B; TNFRSF21; TNFSF11; XCL1; XCR1; CNTFR; GHR; IL12RB1; LIFR |
Intestinal immune network for IgA production | CD80; HLA-DRA; ITGA4 |
Toll-like receptor signaling pathway | CD80; IL1B; PIK3R5; TLR2A; TLR4; FOS |
Phagosome | CTSS; HLA-DRA; MARCO; MRC2; TLR2A; TLR4, NCF2; TUBB6 |
Influenza A | HLA-DRA; IFNGR1; IL18; IL1B; PIK3R5; TLR4; SOCS3 |
TGF-beta signaling pathway | BMP5; BMP6; DCN; ZFYVE16 |
Cytosolic DNA-sensing pathway | IL18; IL1B |
NOD-like receptor signaling pathway | IL18; IL1B |
MAPK signaling pathway | CACNA1D; FGF14; IL1B; NRK; PLA2G4A; PRKCB; PTPN5; RAC2, DUSP5; FOS; PLA2G4A, CACNA1D; CACNA2D1 |
Herpes simplex infection | CD74; HLA-DRA; IFNGR1; IL1B; TLR2A; FOS; SOCS3 |
Salmonella | FOS, PKN3 |
Cell adhesion molecules (CAMs) | SIGLEC1, CD80; VCAM1 |