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Fig. 2 | AMB Express

Fig. 2

From: Secreting-lux/pT-ClyA engineered bacteria suppresses tumor growth via interleukin-1β in two pathways

Fig. 2

Imaging of lux/pT-ClyA-expressing S. typhimurium in a mouse model of cecal colon cancer. BALB/c mice were surgically implanted with CT26 tumors, each measuring 1–2 mm3, with fragments being transplanted onto the ceca colon. Distribution of bacteria visualized by in vivo bioluminescence imaging after injection of engineered Salmonella typhimurium secreting lux/pT-ClyA. Images show representative mice before and after euthanasia. a Bioluminescence image shows that bacteria began to colonize the tumor the third day after the injection of the engineered bacteria into the tail vein. b On the sixth day, mice were dissected. L liver, S spleen, K kidney, H heart, L lung (the above images are from the same mouse)

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