Table 2 Nature of amino-acid substitutions for N-PfCelTOS and CH-PfCelTOS

Hydrophobic to hydrophobic

64, 68, 72, 87, 88, 130, 135, 137, 137, 137, 138, 138, 138, 138

87

Hydrophobic to (+) charged

69, 88, 135, 139

64, 88

Hydrophobic to (−) charged

None observed

None observed

Neutral to hydrophobic

83

None observed

Hydrophobic to neutral

69, 69, 133, 138

None observed

(+) charged to neutral

None observed

None observed

(−) charged to neutral

70

None observed

Polar uncharged to polar uncharged

50, 71, 71

73

Polar uncharged to (+) charged

71, 88, 91

144

Gly/Pro/Ser to hydrophobic

65

None observed

Gly/Pro/Ser to polar uncharged

50, 50

65

Gly/Pro/Ser to Gly/Pro/Ser

84

None observed