Fig. 3

Transport across in vitro BBB model. a P_app of FITC-dextran (500 μg) across polycarbonate membrane in negative group (with hCMEC/D3 cell monolayer) or blank control group (without cell monolayer). b Transcytosis curve of scFab-ANG and scFab with 200 μg. c Transcytosis curve of scFab-ANG (200 μg, 100 μg, 50 μg)