Scientific validation of the antimicrobial and antiproliferative potential of Berberis aristata DC root bark, its phytoconstituents and their biosafety

AMB Express

Table 6 Effect of Berberis aristata diterpenes on biochemical parameters in acute oral toxicity study

Parameters	Male		Female
Parameters	Control*	Treated*	Control*	Treated*
Urea (Mmol/L)	42.633 ± 0.839	42.45 ± 0.476	40.13 ± 0.991	37.933 ± 0.987
Creatinine (µmol/L)	0.774 ± 0.026	0.770 ± 0.009	0.618 ± 0.024	0.566 ± 0.008
Total bilirubin (µmol/L)	2.376 ± 0.093	2.348 ± 0.014	1.76 ± 0.025	1.695 ± 0.015
Aspartate aminotransferase (AST) (U/L)	208.96 ± 4.192	212.13 ± 0.705	160.66 ± 2.708	162.08 ± 0.351
Alanine aminotransferase (ALT) (U/L)	79.95 ± 2.095	77.80 ± 0.566	61.33 ± 2.677	64.186 ± 0.520
Alkaline phosphatase (ALP) (U/L)	258.3 ± 2.510	260.3 ± 0.813	183.33 ± 1.612	185.13 ± 0.305

* Values are expressed as mean ± SEM (n = 6 for each group). There was no significant difference (p > 0.05) between the test and control groups as indicated by Post hoc Tukey’s t-test