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Table 6 Effect of Berberis aristata diterpenes on biochemical parameters in acute oral toxicity study

From: Scientific validation of the antimicrobial and antiproliferative potential of Berberis aristata DC root bark, its phytoconstituents and their biosafety

Parameters Male Female
Control* Treated* Control* Treated*
Urea (Mmol/L) 42.633 ± 0.839 42.45 ± 0.476 40.13 ± 0.991 37.933 ± 0.987
Creatinine (µmol/L) 0.774 ± 0.026 0.770 ± 0.009 0.618 ± 0.024 0.566 ± 0.008
Total bilirubin (µmol/L) 2.376 ± 0.093 2.348 ± 0.014 1.76 ± 0.025 1.695 ± 0.015
Aspartate aminotransferase (AST) (U/L) 208.96 ± 4.192 212.13 ± 0.705 160.66 ± 2.708 162.08 ± 0.351
Alanine aminotransferase (ALT) (U/L) 79.95 ± 2.095 77.80 ± 0.566 61.33 ± 2.677 64.186 ± 0.520
Alkaline phosphatase (ALP) (U/L) 258.3 ± 2.510 260.3 ± 0.813 183.33 ± 1.612 185.13 ± 0.305
  1. * Values are expressed as mean ± SEM (n = 6 for each group). There was no significant difference (p > 0.05) between the test and control groups as indicated by Post hoc Tukey’s t-test