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Table 3 Antimicrobial activity of phytoconstituents isolated from Berberis aristata root bark and its comparison to standard antibiotics (gentamicin, chloramphenicol and amphotericin B)

From: Scientific validation of the antimicrobial and antiproliferative potential of Berberis aristata DC root bark, its phytoconstituents and their biosafety

Test-microorganismd Average zone of inhibition (mm)b Gentamicin Chloramphenicol
Alkaloids Flavonoids Diterpenes
SA 16.66 ± 0.333 29.33 ± 0.333 27.33 ± 0.333 34.5 ± 0.50 26 ± 1.00
SE 16.66 ± 0.333 16.33 ± 0.333 18.66 ± 0.333 26.5 ± 0.50 28.5 ± 0.50
EC 13.33 ± 0.333 17.66 ± 0.666 19.66 ± 0.333 31 ± 1.00 25 ± 0
EF 12.33 ± 0.333 24.66 ± 0.333 29.66 ± 0.333 27.5 ± 0.50 26.5 ± 0.50
KP1 21.33 ± 0.333 31.3 ± 0.333 35.66 ± 0.333 40.5 ± 0.50 38 ± 1.00
KP2 21 ± 0 35.6 ± 0.333 35.33 ± 0.333 37.5 ± 1.50 26.5 ± 0.50
SF 0a 0 16.66 ± 0.333 30.5 ± 0.50 27.5 ± 0.50
ST1 0 0 0 35 ± 0 23 ± 0
ST2 16.66 ± 0.333 30.33 ± 0.333 27.33 ± 0.333 43 ± 1.00 40.5 ± 0.50
PA 14.33 ± 0.333 13.66 ± 0.333 42.66 ± 0.333 40.5 ± 0.50 28.5 ± 0.50
CA 23.3 ± 0.666 33.66 ± 0.333 42.33 ± 0.333 36.5 ± 0.50c ND
CT 0 30 ± 0.577 30.66 ± 0.333 27.5 ± 0. 50c ND
MRSA 15 ± 0 28.33 ± 0.666 36.33 ± 0.333 42 ± 0 39.5 ± 0.50
  1. ND, not done
  2. aNo activity
  3. bValues are expressed as mean ± standard error of means (SEM) of three determinations
  4. cAmphotericin B
  5. dTest-microorganism—SA, Staphylococcus aureus; SE, Staphylococcus epidermidis; EC, Escherichia coli; KP1, Klebsiella pneumoniae 1; KP2, Klebsiella pneumoniae 2; SF, Shigella flexneri; ST1, Salmonella typhimurium 1; ST2, Salmonella typhimurium 2; PA, Pseudomonas aeruginosa; CA, Candida albicans; CT, Candida tropicalis; MRSA, methicillin-resistant Staphylococcus aureus
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