AMB Express

Table 3 Effect of various concentrations of salt on the antibacterial activity of peptides against P. aeruginosa ATCC 27853 and S. aureus ATCC 25923

From: Mechanism of action of antimicrobial peptide P5 truncations against Pseudomonas aeruginosa and Staphylococcus aureus

	10 mM SP buffer (pH 7.2)	MIC (µM)
		NaCl			MgCl₂			FeCl₃
		50 mM	100 mM	150 mM	0.5 mM	1 mM	2 mM	1 µM	4 µM	8 µM
P. aeruginosa ATCC 27853
P5	3.13	3.13	3.13	3.13	3.13	3.13	6.25	3.13	3.13	3.13
P5-CT1	1.56	3.13	3.13	3.13	6.25	6.25	12.5	3.13	3.13	3.13
P5-CT2	6.25	12.5	25	> 25	> 25	> 25	> 25	6.25	6.25	6.25
P5-CT3	> 25	> 25	> 25	> 25	> 25	> 25	> 25	> 25	> 25	> 25
P5-NT1	1.56	3.13	3.13	3.13	6.25	6.25	25	3.13	3.13	3.13
P5-NT2	3.13	6.25	6.25	12.5	12.5	25	> 25	3.13	3.13	3.13
P5-NT3	6.25	6.25	12.5	12.5	12.5	25	> 25	6.25	6.25	6.25
S. aureus ATCC 25923
P5	1.56	1.56	1.56	1.56	1.56	1.56	1.56	1.56	1.56	1.56
P5-CT1	1.56	0.78	0.78	0.78	0.78	0.78	0.78	0.78	0.78	0.78
P5-CT2	1.56	0.78	1.56	1.56	0.78	0.78	1.56	0.78	0.78	0.78
P5-CT3	3.13	3.13	12.5	12.5	3.13	3.13	6.25	1.56	3.13	3.13
P5-NT1	1.56	0.78	0.78	0.78	0.78	0.78	0.78	0.78	0.78	0.78
P5-NT2	1.56	1.56	0.78	0.78	0.78	0.78	1.56	1.56	0.78	1.56
P5-NT3	1.56	0.78	0.78	0.78	0.78	0.78	0.78	0.78	0.78	0.78

MIC minimum inhibitory concentration, CT C-terminus, NT N-terminus

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