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Table 8 Minimum inhibitory concentration (MIC) and fractional inhibitory concentration (FIC) of seed oil, each antibiotic alone and their combination against MDR pathogenic bacterial isolates

From: Comprehensive investigation on the synergistic antibacterial activities of Jatropha curcas pressed cake and seed oil in combination with antibiotics

Strain   MICa (mg/mL)/MICb (µg/mL) FIC FICI Output
Compound Alone Combined
MRSA1 Oil/Ctx 50/100 100/50 2/0.5 2.5 Indifference
Oil/R 50/100 100/50 –/0.5 ND ND
Oil/Of 50/100 3.125/1.56 0.06/0.01 0.07 Synergistic
Oil/Cip 50/50 100/50 –/1 ND ND
Oil/Mox 50/1.56 25/12.5 –/8.01 ND ND
MRSA2 Oil/Ctx –/100 25/12.5 –/0.1 ND ND
Oil/R –/3.125 25/12.5 –/4 ND ND
Oil/Of –/25 1.56/0.78 –/0.06 ND ND
Oil/Cip –/50 1.56/0.78 –/0.03 ND ND
Oil/Mox –/0.781 6.25/3.125 –/4 ND ND
MRSA3 Oil/Ctx –/50 3.125/1.56 –/0.03 ND ND
Oil/R –/3.125 3.125/1.56 –/0.03 ND ND
Oil/Of –/50 50/25 –/0.0078 ND ND
Oil/Cip –/12.5 25/12.5 –/0.03 ND ND
Oil/Mox –/0.39 3.125/1.56 –/8.01 ND ND
MRSA4 Oil/Ctx –/50 0.39/0.195 –/0.003 ND ND
Oil/R –/3.125 3.125/1.56 –/0.49 ND ND
Oil/Of –/1.56 1.56/0.78 –/0.5 ND ND
Oil/Cip –/3.125 3.125/1.56 –/0.49 ND ND
Oil/Mox –/0.781 100/50 –/1.99 ND ND
MRSA5 Oil/Ctx –/3.125 50/25 –/8 ND ND
Oil/R –/3.125 0.78/0.39 –/0.12 ND ND
Oil/Of –/100 12.5/6.25 –/0.06 ND ND
Oil/Cip –/50 100/50 –/1 ND ND
Oil/Mox –/1.56 6.25/3.125 –/32 ND ND
A. baumannii MDR Oil/Ctx –/6.25 3.125/1.56 –/0.24 ND ND
Oil/R –/3.125 0.195/0.097 –/0.03 ND ND
Oil/Of –/0.78 0.78/0.3 –/0.5 ND ND
Oil/Cip –/6.25 0.78/0.39 –/0.06 ND ND
Oil/Mox –/1.56 3.125/1.56 –/1 ND ND
K. pneumoniae Oil/Ctx –/100 100/50 –/0.5 ND ND
Oil/R –/100 100/50 –/0.5 ND ND
Oil/Of –/25 100/50 –/2 ND ND
Oil/Cip –/50 12.5/6.25 –/0.12 ND ND
Oil/Mox –/1.56 6.25/3.125 –/2 ND ND
P. chlororaphis Oil/Ctx –/– –/– –/– ND ND
Oil/R –/100 1.56/0.78 –/0.0078 ND ND
Oil/Of –/6.25 100/50 –/8 ND ND
Oil/Cip –/3.125 3.125/1.56 –/0.4 ND ND
Oil/Mox –/1.56 6.253.125 –/2 ND ND
P. monteilii Oil/Ctx –/100 6.25/3.125 –/0.03 ND ND
Oil/R –/– 0.78/0.39 –/– ND ND
Oil/Of –/100 0.78/0.39 –/0.0039 ND ND
Oil/Cip –/50 0.78/0.39 –/0.0078 ND ND
Oil/Mox –/0.781 100/50 –/64 ND ND
  1. MICa minimal inhibitory concentration for seed oil when applied alone, MICb minimal inhibitory concentration for antibiotic when applied alone, Me methanolic extract, Ctx cefotaxime, R rifampicin, Of ofloxacin, Cip ciprofloxacin, Mox moxifloxacin, ND not determined