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Table 6 Minimum inhibitory concentration (MIC) and fractional inhibitory concentration (FIC) of n-hexane extract, each antibiotic alone and their combination against MDR pathogenic bacterial isolates

From: Comprehensive investigation on the synergistic antibacterial activities of Jatropha curcas pressed cake and seed oil in combination with antibiotics

Strain

Compound

MICa (mg/mL)/MICb (µg/mL)

FIC

FICI

Output

Alone

Combined

MRSA1

n-hex/Ctx

100/100

12.5/6.25

0.1/0.06

0.1

Synergistic

n-hex/R

100/100

100/50

1/0.5

1.5

Indifference

n-hex/Of

100/100

100/50

1/0.5

1.5

Indifference

n-hex/Cip

100/50

100/50

2/1

3

Indifference

n-hex/Mox

100/1.56

100/50

1/32

33.05

Antagonistic

MRSA2

n-hex/Ctx

–/100

6.25/3.125

–/0.03

ND

ND

n-hex/R

–/3.125

12.5/6.25

–/2

ND

ND

n-hex/Of

–/25

1.56/0.78

–/0.03

ND

ND

n-hex/Cip

–/50

0.39/0.195

0.007/0.003

0.01

Synergistic

n-hex/Mox

–/0.78

25/12.5

–/16

ND

ND

MRSA3

n-hex/Ctx

100/50

25/12.5

0.25/0.25

0.5

Synergistic

n-hex/R

100/3.125

1.56/0.78

0.01/0.2

0.2

Synergistic

n-hex/Of

100/50

100/50

0.01/1

1.01

Indifference

n-hex/Cip

100/12.5

100/50

2/4

6.0

Antagonistic

n-hex/Mox

100/0.39

6.25/3.125

0.1/8

8.13

Antagonistic

MRSA4

n-hex/Ctx

100/50

12.5/6.25

0.1/0.1

0.25

Synergistic

n-hex/R

100/3.125

3.125/1.56

0.03/0.4

0.5

Synergistic

n-hex/Of

100/1.56

1.56/0.78

1/0.5

1.5

Indifference

n-hex/Cip

100/3.125

1.56/0.78

0.01/0.2

0.2

Synergistic

n-hex/Mox

100/0.78

100/50

1/64

65

Antagonistic

MRSA5

n-hex/Ctx

100/3.125

6.25/3.125

0.06/1

1.06

Indifference

n-hex/R

100/3.125

0.39/0.195

0.003/0.06

0.06

Synergistic

n-hex/Of

100/100

100/50

0.01/0.5

0.5

Synergistic

n-hex/Cip

100/50

100/50

1/1

2.0

Indifference

n-hex/Mox

100/1.56

6.253.125

0.6/2

2.0

Indifference

baumannii MDR

n-hex/Ctx

–/6.25

3.125/1.56

–/0.2

ND

ND

n-hex/R

–/3.125

0.39/0.195

–/0.06

ND

ND

n-hex/Of

–/0.78

1.56/0.78

–/1

ND

ND

n-hex/Cip

–/6.25

1.56/0.78

–/0.1

ND

ND

n-hex/Mox

–/1.56

6.25/3.125

–/2

ND

ND

K. pneumoniae

n-hex/Ctx

–/100

100/50

–/0.5

ND

ND

n-hex/R

–/100

100/50

–/0.5

ND

ND

n-hex/Of

–/25

100/50

–/2

ND

ND

n-hex/Cip

–/50

100/50

–/1

ND

ND

n-hex/Mox

–/1.56

12.5/6.25

–/4

ND

ND

P. chlororaphis

n-hex/Ctx

–/–

–/50

–/–

ND

ND

n-hex/R

–/100

100/50

–/0.5

ND

ND

n-hex/Of

–/6.25

100/50

–/8

ND

ND

n-hex/Cip

–/3.125

50/25

–/8

ND

ND

n-hex/Mox

–/1.56

12.5/6.25

–/4

ND

ND

P. monteilii

n-hex/Ctx

–/100

0.78/0.39

–/–

ND

ND

n-hex/R

–/–

0.78/0.39

–/–

ND

ND

n-hex/Of

–/100

1.56/0.78

–/0.007

ND

ND

n-hex/Cip

–/50

1.56/0.78

–/0.01

ND

ND

n-hex/Mox

–/0.78

100/50

–/64

ND

ND

  1. MICa minimal inhibitory concentration for n-hexane extract when applied alone, MICb minimal inhibitory concentration for antibiotic when applied alone, Me methanolic extract, Ctx cefotaxime, R rifampicin, Of ofloxacin, Cip ciprofloxacin, Mox moxifloxacin, ND not determined