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Table 6 Minimum inhibitory concentration (MIC) and fractional inhibitory concentration (FIC) of n-hexane extract, each antibiotic alone and their combination against MDR pathogenic bacterial isolates

From: Comprehensive investigation on the synergistic antibacterial activities of Jatropha curcas pressed cake and seed oil in combination with antibiotics

Strain Compound MICa (mg/mL)/MICb (µg/mL) FIC FICI Output
Alone Combined
MRSA1 n-hex/Ctx 100/100 12.5/6.25 0.1/0.06 0.1 Synergistic
n-hex/R 100/100 100/50 1/0.5 1.5 Indifference
n-hex/Of 100/100 100/50 1/0.5 1.5 Indifference
n-hex/Cip 100/50 100/50 2/1 3 Indifference
n-hex/Mox 100/1.56 100/50 1/32 33.05 Antagonistic
MRSA2 n-hex/Ctx –/100 6.25/3.125 –/0.03 ND ND
n-hex/R –/3.125 12.5/6.25 –/2 ND ND
n-hex/Of –/25 1.56/0.78 –/0.03 ND ND
n-hex/Cip –/50 0.39/0.195 0.007/0.003 0.01 Synergistic
n-hex/Mox –/0.78 25/12.5 –/16 ND ND
MRSA3 n-hex/Ctx 100/50 25/12.5 0.25/0.25 0.5 Synergistic
n-hex/R 100/3.125 1.56/0.78 0.01/0.2 0.2 Synergistic
n-hex/Of 100/50 100/50 0.01/1 1.01 Indifference
n-hex/Cip 100/12.5 100/50 2/4 6.0 Antagonistic
n-hex/Mox 100/0.39 6.25/3.125 0.1/8 8.13 Antagonistic
MRSA4 n-hex/Ctx 100/50 12.5/6.25 0.1/0.1 0.25 Synergistic
n-hex/R 100/3.125 3.125/1.56 0.03/0.4 0.5 Synergistic
n-hex/Of 100/1.56 1.56/0.78 1/0.5 1.5 Indifference
n-hex/Cip 100/3.125 1.56/0.78 0.01/0.2 0.2 Synergistic
n-hex/Mox 100/0.78 100/50 1/64 65 Antagonistic
MRSA5 n-hex/Ctx 100/3.125 6.25/3.125 0.06/1 1.06 Indifference
n-hex/R 100/3.125 0.39/0.195 0.003/0.06 0.06 Synergistic
n-hex/Of 100/100 100/50 0.01/0.5 0.5 Synergistic
n-hex/Cip 100/50 100/50 1/1 2.0 Indifference
n-hex/Mox 100/1.56 6.253.125 0.6/2 2.0 Indifference
baumannii MDR n-hex/Ctx –/6.25 3.125/1.56 –/0.2 ND ND
n-hex/R –/3.125 0.39/0.195 –/0.06 ND ND
n-hex/Of –/0.78 1.56/0.78 –/1 ND ND
n-hex/Cip –/6.25 1.56/0.78 –/0.1 ND ND
n-hex/Mox –/1.56 6.25/3.125 –/2 ND ND
K. pneumoniae n-hex/Ctx –/100 100/50 –/0.5 ND ND
n-hex/R –/100 100/50 –/0.5 ND ND
n-hex/Of –/25 100/50 –/2 ND ND
n-hex/Cip –/50 100/50 –/1 ND ND
n-hex/Mox –/1.56 12.5/6.25 –/4 ND ND
P. chlororaphis n-hex/Ctx –/– –/50 –/– ND ND
n-hex/R –/100 100/50 –/0.5 ND ND
n-hex/Of –/6.25 100/50 –/8 ND ND
n-hex/Cip –/3.125 50/25 –/8 ND ND
n-hex/Mox –/1.56 12.5/6.25 –/4 ND ND
P. monteilii n-hex/Ctx –/100 0.78/0.39 –/– ND ND
n-hex/R –/– 0.78/0.39 –/– ND ND
n-hex/Of –/100 1.56/0.78 –/0.007 ND ND
n-hex/Cip –/50 1.56/0.78 –/0.01 ND ND
n-hex/Mox –/0.78 100/50 –/64 ND ND
  1. MICa minimal inhibitory concentration for n-hexane extract when applied alone, MICb minimal inhibitory concentration for antibiotic when applied alone, Me methanolic extract, Ctx cefotaxime, R rifampicin, Of ofloxacin, Cip ciprofloxacin, Mox moxifloxacin, ND not determined