Table 5 Minimum inhibitory concentration (MIC) and fractional inhibitory concentration (FIC) of methanolic extract, each antibiotic alone and their combination against MDR pathogenic bacterial isolates

MRSA1

Me/Ctx

50/100

50/25

0.5/2

2.5

Indifference

Me/R

50/100

100/50

0.5/2

2.5

Indifference

Me/Of

50/100

100/50

0.5/2

2.5

Indifference

Me/Cip

50/50

25/12.5

0.5/0.25

0.75

Additive

Me/Mox

50/1.56

25/12.5

0.5/8.01

8.51

Antagonistic

MRSA2

Me/Ctx

50/100

50/25

1/4

5.0

Antagonistic

Me/R

50/3.125

1.56/0.78

0.03/0.24

0.28

Synergistic

Me/Of

50/25

100/50

2/2

4.0

Indifference

Me/Cip

50/50

50/25

1/0.5

1.5

Indifference

Me/Mox

50/0.781

12.5/6.25

0.25/8

8.25

Antagonistic

MRSA3

Me/Ctx

50/50

50/25

1/0.5

1.5

Indifference

Me/R

50/3.125

0.19/0.09

0.003/0.006

0.01

Synergistic

Me/Of

50/50

50/25

1/0.5

1.5

Indifference

Me/Cip

50/12.5

25/12.5

0.5/1

1.5

Indifference

Me/Mox

50/0.39

3.125/1.56

0.06/4

4.06

Antagonistic

MRSA4

Me/Ctx

100/50

1.56/0.78

0.01/0.01

0.03

Synergistic

Me/R

100/3.125

0.78/0.39

0.007/0.12

0.13

Synergistic

Me/Of

100/1.56

0.78/0.78

0.007/0.5

0.5

Synergistic

Me/Cip

100/3.125

1.56/0.39

0.01/0.12

0.14

Synergistic

Me/Mox

100/0.781

25/12.5

0.25/16

16.25

Antagonistic

MRSA5

Me/Ctx

100/3.125

100/50

1/16

17

Antagonistic

Me/R

100/3.125

0.78/0.39

0.007/0.12

0.13

Synergistic

Me/Of

100/100

50/25

0.5/4

4.5

Antagonistic

Me/Cip

100/50

50/25

0.5/0.5

1.0

Indifference

Me/Mox

100/1.56

6.25/3.125

0.06/2

2.06

Indifference

A. baumannii MDR

Me/Ctx

100/6.25

3.12/1.56

0.03/0.24

0.2

Synergistic

Me/R

100/3.125

0.39/0.195

0.003/0.06

0.06

Synergistic

Me/Of

100/0.78

1.56/0.78

0.01/1

1.01

Indifference

Me/Cip

100/6.25

0.39/0.195

0.003/0.03

0.03

Synergistic

Me/Mox

100/1.56

6.25/3.125

0.06/2

2.0

Indifference

K. pneumoniae

Me/Ctx

100/100

100/50

1/2

3.0

Indifference

Me/R

100/100

50/25

0.5/0.25

0.75

Additive

Me/Of

100/25

50/25

0.5/0.03

0.5

Synergistic

Me/Cip

100/50

50/25

0.5/0.003

0.5

Synergistic

Me/Mox

100/1.56

12.5/6.25

0.12/4

4.13

Antagonistic

P. chlororaphis

Me/Ctx

100/–

25/12.5

0.25/–

ND

ND

Me/R

100/100

25/12.5

0.25/0.125

0.38

Synergistic

Me/Of

100/6.25

100/50

1/0.12

1.12

Indifference

Me/Cip

100/3.125

12.5/6.25

0.12/0.06

0.18

Synergistic

Me/Mox

100/1.56

3.125/1.56

0.03/1

1.03

Indifference

P. monteilii

Me/Ctx

–/100

0.39/0.195

–/512

ND

ND

Me/R

–/–

0.39/0.195

–/–

ND

ND

Me/Of

–/100

0.78/0.39

–/256

ND

ND

Me/Cip

–/50

0.39/0.195

–/0.003

ND

ND

Me/Mox

–/0.78

100/50

–/64

ND

ND