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Table 3 Minimum inhibitory concentration (MIC) and fractional inhibitory concentration (FIC) of aqueous extract, each antibiotic and their combination against clinical pathogenic and reference bacterial isolates

From: Comprehensive investigation on the synergistic antibacterial activities of Jatropha curcas pressed cake and seed oil in combination with antibiotics

Strain Compound MICa (mg/mL)/MICb (µg/mL) FIC FICI Output
Alone Combined
A. baumannii Aq/Ctx 200/0.19 0.195/0.097 0.0009/0.5 0.5 Synergistic
Aq/R 200/6.25 1.56/0.78 0.007/0.12 0.1 Synergistic
Aq/Of 200/12.5 3.125/1.56 0.03/0.12 0.1 Synergistic
Aq/Cip 200/6.25 1.56/0.78 0.007/0.12 0.1 Synergistic
Aq/Mox 200/6.25 12.5/6.25 0.12/1 1.125 Indifference
E. coli Aq/Ctx –/100 100/50 –/0.5 ND ND
Aq/R –/100 3.125/1.56 –/0.01 ND ND
Aq/Of –/50 6.25/3.125 –0.06 ND ND
Aq/Cip –/100 6.25/3.125 –/0.03 ND ND
Aq/Mox –/3.125 25/12.5 –/4 ND ND
E. faecalis Aq/Ctx –/50 100/50 –/1 ND ND
Aq/R –/100 1.56/0.78 –/0.007 ND ND
Aq/Of –/12.5 1.56/0.78 –/0.06 ND ND
Aq/Cip –/50 3.125/1.56 –/0.03 ND ND
Aq/Mox –/1.56 50/25 –/16 ND ND
P. vulgaris Aq/Ctx –/0.19 6.25/3.125 –/0.5 ND ND
Aq/R –/6.25 6.25/3.125 –/0.5 ND ND
Aq/Of –/12.5 0.78/0.39 –/0.03 ND ND
Aq/Cip –/6.25 0.78/0.39 –/0.06 ND ND
Aq/Mox –/6.25 –/– –/– ND ND
S. aureus Aq/Ctx –/50 100/50 –/1 ND ND
Aq/R –/6.25 100/50 –/8 ND ND
Aq/Of –/100 6.25/3.125 –/0.25 ND ND
Aq/Cip –/12.5 50/25 –/2 ND ND
Aq/Mox –/3.125 50/25 –/8 ND ND
P. aeruginosa Aq/Ctx 200/50 100/50 0.5/1 1.5 Indifference
Aq/R 200/6.25 12.5/6.25 0.06/1 1.06 Indifference
Aq/Of 200/12.5 12.5/6.25 0.06/0.5 0.5 Synergistic
Aq/Cip 200/3.125 25/12.5 0.12/4 4.1 Antagonistic
Aq/Mox 200/0.39 6.25/3.125 0.03/8 8.0 Antagonistic
S. aureus (ATCC) Aq/Ctx 200/100 100/50 0.5/0.5 1.0 Indifference
Aq/R 200/6.25 100/50 0.5/8 8.5 Antagonistic
Aq/Of 200/3.12 3.125/1.56 0.5/0.4 0.9 Additive
Aq/Cip 200/1.56 12.5/6.25 0.06/4 4.06 Antagonistic
Aq/Mox 200/0.78 12.5/6.25 0.06/8 8.0 Antagonistic
E. coli (ATCC) Aq/Ctx –/0.78 1.56/0.78 –/1 ND ND
Aq/R –/6.25 1.56/0.78 –/0.1 ND ND
Aq/Of –/3.12 3.125/1.56 –/0.4 ND ND
Aq/Cip –/3.12 1.56/0.78 –/0.2 ND ND
Aq/Mox –/0.39 12.5/6.25 –/16 ND ND
  1. MICa minimal inhibitory concentration for aqueous extract when applied alone, MICb minimal inhibitory concentration for antibiotic when applied alone, Me methanolic extract, Ctx cefotaxime, R rifampicin, Of ofloxacin, Cip ciprofloxacin, Mox moxifloxacin, ND not determined