|
Virus
|
No. detected (MNCP/RIDT)a
|
Sensitivity (%) (95% CI)
|
Specificity (%) (95% CI)
|
PPVs (%) (95% CI)
|
NPVs (%) (95% CI)
|
Overall concordance rate (%) (95% CI)
|
P value (McNemar’s test)
|
Kappa value (95% CI)
|
|---|
|
+/+
|
+/−
|
−/+
|
−/−
|
|---|
|
Influenza A
|
20
|
74
|
0
|
161
|
100.00 (79.95–100.00)
|
68.51 (62.10–74.31)
|
21.28 (13.78–31.17)
|
100.00 (97.10–100.00)
|
70.98 (65.41–76.55
|
< 0.001
|
0.25** (0.11–0.40)
|
|
Influenza B
|
54
|
41
|
1
|
163
|
98.18 (89.00–99.91)
|
79.90 (73.61–85.04)
|
56.84 (46.29–66.84)
|
99.39 (96.14–99.97)
|
83.78 (79.29–88.27)
|
< 0.001
|
0.62** (0.51–0.72)
|
- +: positive; −: negative; MNCP: micro/nanofluidic chip platform; RIDT: rapid influenza diagnostic test; CI: confidence interval; PPVs: positive predictive values; NPVs: negative predictive values
- **P < 0.001 (kappa statistics)
- aMNCP and RIDT were conducted successively in 255 of 266 patients to detect influenza A virus and in 259 of 266 patients to detect influenza B virus
