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Table 5 Results of the MNCP assay for influenza A and B virus detection and compared with RIDT

From: Evaluation of a novel micro/nanofluidic chip platform for the detection of influenza A and B virus in patients with influenza-like illness

Virus No. detected (MNCP/RIDT)a Sensitivity (%) (95% CI) Specificity (%) (95% CI) PPVs (%) (95% CI) NPVs (%) (95% CI) Overall concordance rate (%) (95% CI) P value (McNemar’s test) Kappa value (95% CI)
+/+ +/− −/+ −/−
Influenza A 20 74 0 161 100.00 (79.95–100.00) 68.51 (62.10–74.31) 21.28 (13.78–31.17) 100.00 (97.10–100.00) 70.98 (65.41–76.55 < 0.001 0.25** (0.11–0.40)
Influenza B 54 41 1 163 98.18 (89.00–99.91) 79.90 (73.61–85.04) 56.84 (46.29–66.84) 99.39 (96.14–99.97) 83.78 (79.29–88.27) < 0.001 0.62** (0.51–0.72)
  1. +: positive; −: negative; MNCP: micro/nanofluidic chip platform; RIDT: rapid influenza diagnostic test; CI: confidence interval; PPVs: positive predictive values; NPVs: negative predictive values
  2. **P < 0.001 (kappa statistics)
  3. aMNCP and RIDT were conducted successively in 255 of 266 patients to detect influenza A virus and in 259 of 266 patients to detect influenza B virus