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Table 5 Results of the MNCP assay for influenza A and B virus detection and compared with RIDT

From: Evaluation of a novel micro/nanofluidic chip platform for the detection of influenza A and B virus in patients with influenza-like illness

Virus

No. detected (MNCP/RIDT)a

Sensitivity (%) (95% CI)

Specificity (%) (95% CI)

PPVs (%) (95% CI)

NPVs (%) (95% CI)

Overall concordance rate (%) (95% CI)

P value (McNemar’s test)

Kappa value (95% CI)

+/+

+/−

−/+

−/−

Influenza A

20

74

0

161

100.00 (79.95–100.00)

68.51 (62.10–74.31)

21.28 (13.78–31.17)

100.00 (97.10–100.00)

70.98 (65.41–76.55

< 0.001

0.25** (0.11–0.40)

Influenza B

54

41

1

163

98.18 (89.00–99.91)

79.90 (73.61–85.04)

56.84 (46.29–66.84)

99.39 (96.14–99.97)

83.78 (79.29–88.27)

< 0.001

0.62** (0.51–0.72)

  1. +: positive; −: negative; MNCP: micro/nanofluidic chip platform; RIDT: rapid influenza diagnostic test; CI: confidence interval; PPVs: positive predictive values; NPVs: negative predictive values
  2. **P < 0.001 (kappa statistics)
  3. aMNCP and RIDT were conducted successively in 255 of 266 patients to detect influenza A virus and in 259 of 266 patients to detect influenza B virus