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Table 3 Results of the MNCP assay for influenza A and B virus detection and compared with the rRT-PCR test

From: Evaluation of a novel micro/nanofluidic chip platform for the detection of influenza A and B virus in patients with influenza-like illness

Virus No. detected (MNCP/rRT-PCR)a Sensitivity (%) (95% CI) Specificity (%) (95% CI) PPVs (%) (95% CI) NPVs (%) (95% CI) Overall concordance rate (%) (95% CI) P value (McNemar’s test) Kappa value (95% CI)
+/+ +/− −/+ −/−
Influenza A 89 5 1 160 98.89 (93.10 − 99.94) 96.97 (92.70 − 98.88) 94.68 (87.45 − 98.03) 99.38 (96.07 − 99.97) 97.65 (94.70 − 99.04) 0.219 0.95** (0.91 − 0.99)
Influenza B 94 1 5 159 94.95 (88.06 − 98.13) 99.38 (96.04 − 99.97) 98.95 (93.44 − 99.95) 96.95 (92.65 − 98.87) 97.68 (94.78 − 99.05) 0.219 0.95** (0.91 − 0.99)
  1. +: positive; −: negative; MNCP: micro/nanofluidic chip platform; rRT-PCR: real-time reverse transcription polymerase chain reaction; CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value
  2. **P < 0.001 (kappa statistics)
  3. aMNCP and rRT-PCR were conducted successively in 255 of 266 patients to detect influenza A virus (11 were excluded because of sample volume shortage) and in 259 of 266 patients to detect influenza B virus (seven excluded because of sample volume shortage)