Fig. 1
(adopted from Duthie (1999))
How folate deficiency leads to genomic instability? Two way: 5,10-methylene-THF, 5,10-methylenetetrahydrofolate; 5, methyl THF, 5-methylenetetrahydrofolate; THF, tetrahydrofolate; C, cytosine; G, guanine; X denotes no capability to donate a methyl group (CH3); TMP, thymidylate monophosphate; desoxyuridylate monophosphate, dUMP
