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Table 1 Cytotoxic activities of evaluated strains

From: Microbial diversity of saline environments: searching for cytotoxic activities

Strain ID Closed type strain (Accession No) (% similarity) Culture medium Extraction solvent Cytotoxic activity of crude extracts IC50 (µg mL−1)
Cellular line
4T1 MCF7
Actinobacteria
 CG 23 Isoptericola halotolerans (KR476431.1) (98) TSB 8% (w/v) NaCl Chloroform > 250 146.0
TSB 8% (w/v) NaCl Ethyl acetate > 250 53.9
TSB Chloroform
TSB Ethyl acetate
 CG 24 Ornithinimicrobium kibberense (KM406766.1) (99) TSB 8% (w/v) NaCl Chloroform 106.0 > 250
TSB Chloroform
TSB Ethyl acetate > 250 57.2
 CG 12 Janibacter cremeus (KY775504.1) (94) TSB 8% (w/v) NaCl Chloroform 226 34.2
TSB 8% (w/v) NaCl Ethyl acetate > 250 > 250
 CG 35 Nesterenkonia sandarakina (KF924226) (99) TSB 8% (w/v) NaCl Chloroform 117.8 188.6
TSB 8% (w/v) NaCl Ethyl acetate > 250 > 250
 CG 28 Nesterenkonia sandarakina (KF924226) (98) TSB 8% (w/v) NaCl Chloroform
TSB 8% (w/v) NaCl Ethyl acetate
 CG 20 Isoptericola halotolerans (KP972642.1) (99) TSB 8% (w/v) NaCl Chloroform
TSB 8% (w/v) NaCl Ethyl acetate
TSB Chloroform
Firmicutes
 CG 6 Alkalibacterium putridalgicola (AB681988.1) (99) Marine broth Chloroform 134.3 59.9
TSB Chloroform
TSB Ethyl acetate > 250 118.8
 CG 3 Bacillus aquimaris (KC335217.1) (99) TSB Chloroform
TSB Ethyl acetate > 250 87.3
 USBA 882 Bacillus aquimaris (NR_025241.1) (96) Modified marine broth Ethyl acetate 192.0 NT
 USBA 899 Bacillus hemicentroti (NR_025264.1) (97) TSB 3% (w/v) NaCl Chloroform
TSB 3% (w/v) NaCl Ethyl acetate
 CG 13 Bacillus aquimaris (KC335217.1) (92) TSB 80 Chloroform
TSB 80 Ethyl acetate > 250 200.5
 CG 25 Bacillus hwajinpoensis (KR045741.1) (97) TSB 80 Chloroform
TSB 80 Ethyl acetate > 250 56.1
 CG 36 Bacillus aerophilus (KR010180.1) (99) TSB Chloroform 173.2 8.8
 CG 42 Bacillus hwajinpoensis (KX817927.1) (99) TSB 3% (w/v) NaCl Chloroform
TSB Chloroform
 CG 69 Bacillus aerophilus (KU236478.1) (99) TSB Chloroform > 250 224.0
 CG 11 Bacillus altitudinis (NR_118439.1) (99) TSB Chloroform
TSB Ethyl acetate > 250 > 250
 CG 7 Bacillus aquimaris (NR_113995.1) (95) TSB Chloroform
TSB Ethyl acetate > 250 > 250
 CG 69 Bacillus aerophilus (KU236478.1) (99) TSB 3% (w/v) NaCl Chloroform
TSB 3% (w/v) NaCl Ethyl acetate
 CG 15 Bacillus licheniformis (S002290488) (98) TSB Chloroform > 250 136
TSB Ethyl acetate > 250 42.0
Marine broth Chloroform
Marine broth Ethyl acetate > 250 65.6
 USBA 866 Bacillus vietnamensis (NR_025264.1) (97) Modified marine broth Chloroform > 250 185.7
Modified marine broth Ethyl acetate 48.3 65.7
 USBA 867 Bacillus simplex (NR_109010.1) (98) Modified marine broth Ethyl acetate > 250 134.8
 USBA 868 Bacillus hemicentroti (NR_114919.1) (99) Modified marine broth Ethyl acetate 56.2 76.2
 CG 22 Bacillus subtilis (CP021499.1) (100) TSB Chloroform 29.8 76.5
TSB Ethyl acetate 21.7 75.5
 CG 63 Bacillus amyloliquefaciens (KY784657.1) (99) TSB 80 Chloroform 107 76.4
 CG 31 Bacillus weihenstephanensis (HF678914.2) (99) TSB 8% (w/v) NaCl Ethyl acetate 25.4 144.4
 CG 57 Bacillus weihenstephanensis (KY120752.1) (100) TSB Chloroform
TSB Ethyl acetate
 CG 74 Salimicrobium flavidum (EU868860.1) (96) TSB 8% (w/v) NaCl Chloroform
TSB 8% (w/v) NaCl Ethyl acetate
 CG 86 Salimicrobium flavidum (EU868860.1) (96) TSB 8% (w/v) NaCl Chloroform
TSB 8% (w/v) NaCl Ethyl acetate
 CG 88 Salimicrobium flavidum (EU868860.1) (97) TSB 8% (w/v) NaCl Chloroform
TSB 8% (w/v) NaCl Ethyl acetate
Gammaproteobacteria
 CG 76 Halomonas alkaliantarctica (NR_145910.1) (91) TSB 4% (w/v) NaCl Ethyl acetate > 250 96.7
 CG X Halomonas alkaliantarctica (NR_145910.1) (91) TSB 8% (w/v) NaCl Chloroform 82.3 101.3
 CG 60 Halomonas ventosae (NR_044519.1) (93) TSB 8% (w/v) NaCl Chloroform
TSB 8% (w/v) NaCl Ethyl acetate > 250 > 250
 CG 83 Halomonas ventosae (NR_044519.1) (99) TSB 8% (w/v) NaCl Chloroform
TSB 8% (w/v) NaCl Ethyl acetate
 USBA 856 Halomonas ventosae (NR_042812.1) (99) Modified marine broth Chloroform 4.3 217.1
Modified marine broth Ethyl acetate
TSB Ethyl acetate
 CG 78 Halomonas janggokensis (AB042501.2) (92) TSB 8% (w/v) NaCl Chloroform
TSB 8% (w/v) NaCl Ethyl acetate
 CG 66 Halomonas fontilapidosi (KT984005.1) (99) TSB 8% (w/v) NaCl Chloroform
TSB 8% (w/v) NaCl Ethyl acetate
 USBA 873 Halomonas taeanensis (NR_043087.1) (96) TSB 3% (w/v) NaCl Chloroform
TSB 3% (w/v) NaCl Ethyl acetate
 CG 50 Chromohalobacter japonicus (NR_040965) (97) TSB 8% (w/v) NaCl Chloroform 158.6 115
TSB 8% (w/v) NaCl Ethyl acetate
 CG 72 Chromohalobacter japonicus (NR_040965) (99) TSB 8% (w/v) NaCl Chloroform
TSB 8% (w/v) NaCl Ethyl acetate
 CG 55 Chromohalobacter canadensis (NR_114545.1) (98) TSB 8% (w/v) NaCl Chloroform
TSB 8% (w/v) NaCl Ethyl acetate 69.3 137.6
 USBA862 Chromohalobacter japonicus (NR_114545.1) (96) TSB 3% (w/v) NaCl Chloroform
TSB 3% (w/v) NaCl Ethyl acetate
 USBA 861 Chromohalobacter japonicus (NR_114545.1) (95) TSB 3% (w/v) NaCl Chloroform
TSB 3% (w/v) NaCl Ethyl acetate > 250 > 250
 USBA 896 Chromohalobacter canadensis (NR_114545.1) (96) TSB 3% (w/v) NaCl Chloroform
TSB 3% (w/v) NaCl Ethyl acetate
 USBA 344 Shawanella chilikensis (BALO01000089) (99) TSB 3% (w/v) NaCl Chloroform 5.3 67.9
TSB 3% (w/v) NaCl Ethyl acetate 15.3 21.8
 CG 65 Marinobacter persicus (NR_109110.1) (98) TSB 8% (w/v) NaCl Chloroform
TSB 8% (w/v) NaCl Ethyl acetate
Alphaproteobacteria
 CG 82 Salipiger nanhaiensis (NR_134804.1) (98) TSB Ethyl acetate > 250 > 250
 USBA 36 Oceanibaculum indicum (NR_044547.1) (99) TSB 5% (w/v) NaCl Chloroform 173.2 8.8
 USBA 85 Caenispirillum bisanense (NR_04408.1) (98) TSB Chloroform 69.6 90.5
TSB Ethyl acetate 29.5 74.1
 USBA 857 Martelella mediterránea (NR_043068.1) (98) Marine broth Chloroform > 250 > 250
 USBA 371 Labrenzia aggregata (NR_11386.1) (99) TSB 3% (w/v) NaCl Chloroform 5.5 4.5