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Table 1 Summary of water solubility and pharmacological properties of (−)-menthol β-d-glucoside and (−)-menthol

From: Improvement of the pharmacological activity of menthol via enzymatic β-anomer-selective glycosylation

  Water solubility (g/L) Flavor The threshold concentration for cooling (%) Expression of activation marker on THP-1 cells Irritating sensation to the skin
CD54 CD86
Menthol NT Yes 0.125 Positive Negative Yes
Menthol β-glucoside 18.1 No 0.06 Negative Negative No
Controla 0.66 NT NT NT NT NT
  1. NT not tested
  2. aControl for water solubility were menthol α-glucoside