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From: Development of a new method based on unmodified gold nanoparticles and peptide nucleic acids for detecting bovine viral diarrhea virus-RNA

Scheme 1

Schematic illustration of PNA-AuNP colorimetric detection assay. PNA immediately aggregates the AuNPs; however, hybridization of PNA with complementary RNA protects AuNP from aggregation, and the NPs remain stable. Non-complementary RNA did not hybridize with PNA; therefore, AuNP was aggregated in the presence of a charge-neutral PNA

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