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Table 4 Biooxidation of fused cyclobutanones mediated by BVMOLepto

From: Cloning and characterization of the Type I Baeyer–Villiger monooxygenase from Leptospira biflexa

No Substrate BVMO Leptospira biflexa Reference biotransformation using CHMO Acinetobacter sp. NCIMB 9871 as biocatalyst
Conva (%) ee N, ee ABN (%)b Yield (%) ee N, ee ABN (%)b References
N:ABN (%) N:ABN (%)
34 94 50(−), 23(−) 74 95(−), >99(−) Mihovilovic et al. (2005b)
50:50 51:49
35 8 44(−), 95(−) 80 60(−), >95(−) Alphand and Furstoss (1992)
27:73 65:35
36 47 96(nd), >99(nd) 84 44(nd), >99(nd) Mihovilovic et al. (2008)
19:81 70:30
  1. N:ABN ratio of normal:abnormal lactones, nd not determined
  2. aRelative conversion (Conv) of starting material to lactone as determined by chiral phase GC
  3. bEnantiomeric excess for normal lactone (ee N) and abnormal lactone (ee ABN). The sign of specific rotation is indicated in brackets and was assigned according to the literature for reference biotransformations