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Table 3 Biooxidation of substituted cyclic ketones by BVMOLepto

From: Cloning and characterization of the Type I Baeyer–Villiger monooxygenase from Leptospira biflexa

No Substrate Conv (%)a ee P (%)b
19 55 68(−)
20 36 98(−)
21 97 nd
22 16 88(−)
23 nc na
24 nc na
25 nc na
26 86 nd
27 98 nd
28 nc na
29 nc na
30 nc na
31 9 21(+)
32 5 27(+)
33 nc na
  1. nc no conversion, nd not determined, na not applicable
  2. aRelative conversion (Conv) of starting material to lactone as determined by GC
  3. bEnantiomeric excess of the product (ee P) was determined by chiral phase GC. The sign of specific rotation is indicated in brackets and was assigned according to the literature for reference biotransformations