Application of response surface methodology for optimization of medium components for the production of secondary metabolites by Streptomyces diastatochromogenes KX852460

AMB Express

Table 3 Coded coefficients for antifungal activity

Term	Effect	Coef	SE Coef	T-value	P-value	VIF
Constant		32.034	0.807	39.70	0.000
X₁	2.097	1.048	0.413	2.54	0.022	1.00
X₂	1.053	0.527	0.413	1.28	0.220	1.00
X₃	5.508	2.754	0.413	6.67	0.000	1.00
X₄	3.312	1.656	0.413	4.01	0.001	1.00
X₅	1.620	0.810	0.413	1.96	0.067	1.00
X ²₁ X₁	−6.363	−3.182	0.373	−8.52	0.000	1.02
X ²₂ X₂	−5.888	−2.944	0.373	−7.88	0.000	1.02
X ²₃ X₃	−9.031	−4.515	0.373	−12.09	0.000	1.02
X ²₄ X₄	−9.826	−4.913	0.373	−13.15	0.000	1.02
X ²₅ X₅	−5.688	−2.844	0.373	−7.61	0.000	1.02
X ²₁ X₂	2.670	1.335	0.506	2.64	0.018	1.00
X ²₁ X₅	−4.880	−2.440	0.506	−4.82	0.000	1.00
X ²₂ X₄	−4.220	−2.110	0.506	−4.17	0.001	1.00
X ²₂ X₅	−4.820	−2.410	0.506	−4.77	0.000	1.00
X ²₄ X₅	−7.320	−3.660	0.506	−7.24	0.000	1.00