Fig. 5
Lung histopathology from different NZ2114 concentration experimental groups. ICR female mice were inoculated with 1 × 108 CFU S. suis CVCC606 and various concentration of NZ2114 (10, 20, and 40 mg/kg) was injected after 1 and 8 h post-infection. The mice were sacrificed after 24 h post-treatment and lung tissue was collected for histological evaluation. a Control group; b S. suis CVCC606 infection group; c S. suis CVCC606 + 10 mg/kg NZ2114; d S. suis CVCC606 + 20 mg/kg NZ2114; e S. suis CVCC606 + 40 mg/kg NZ2114; f S. suis CVCC606 + 20 mg/kg ampicillin. A alveoli, T bronchioli terminals, V vessel, 1 infiltration of inflammatory cells, 2 alveolar collapse, 3 alveolar hemorrhage, 4 bronchioli terminals epithelium damage