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AMB Express

Table 4 Combination effects of H1, H2, H3 with traditional antibiotics against S. aureus

From: Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus

Combination

Variety

S. aureus ATCC43300

MICa (μM)

MICc (μM)

FIC

FICI

H1-Van

H1

0.056

0.056

1

2

Van

0.714

0.714

1

H1-Amp

H1

0.056

0.014

0.25

1.25

Amp

5.724

5.724

1

H1-Rif

H1

0.056

0.056

1

2

Rif

0.019

0.019

1

H1-Cip

H1

0.056

0.028

0.5

1.5

Cip

1.510

1.510

1

H2-Van

H2

0.113

0.113

1

2

Van

0.714

0.714

1

H2-Amp

H2

0.113

0.113

1

3

Amp

5.724

11.450

2

H2-Rif

H2

0.113

0.056

0.5

1.5

Rif

0.019

0.019

1

H2-Cip

H2

0.113

0.227

2

2.5

Cip

1.510

0.755

0.5

H3-Van

H3

0.056

0.028

0.5

1.5

Van

0.714

0.714

1

H3-Amp

H3

0.056

0.056

1

3

Amp

5.724

11.450

2

H3-Rif

H3

0.056

0.056

1

3

Rif

0.019

0.038

2

H3-Cip

H3

0.056

0.056

1

1.5

Cip

1.510

0.755

0.5

  1. Van vancomycin, Amp ampicillin, Rif rifampicin, Cip ciprofloxacin, H1-Van, H2-Van, H3-Van H1, H2, H3 in combination with vancomycin, respectively, H1-Amp, H2-Amp, H3-Amp H1, H2, H3 in combination with ampicillin, respectively, H1-Rif, H2-Rif, H3-Rif H1, H2, H3 in combination with rifampicin, respectively, H1-Cip, H2-Cip, H3-Cip, H1, H2, H3 in combination with ciprofloxacin, respectively, MIC a the MIC of drug alone, MIC c the MIC of the most effective combination
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