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Table 4 Combination effects of H1, H2, H3 with traditional antibiotics against S. aureus

From: Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus

Combination Variety S. aureus ATCC43300
MICa (μM) MICc (μM) FIC FICI
H1-Van H1 0.056 0.056 1 2
Van 0.714 0.714 1
H1-Amp H1 0.056 0.014 0.25 1.25
Amp 5.724 5.724 1
H1-Rif H1 0.056 0.056 1 2
Rif 0.019 0.019 1
H1-Cip H1 0.056 0.028 0.5 1.5
Cip 1.510 1.510 1
H2-Van H2 0.113 0.113 1 2
Van 0.714 0.714 1
H2-Amp H2 0.113 0.113 1 3
Amp 5.724 11.450 2
H2-Rif H2 0.113 0.056 0.5 1.5
Rif 0.019 0.019 1
H2-Cip H2 0.113 0.227 2 2.5
Cip 1.510 0.755 0.5
H3-Van H3 0.056 0.028 0.5 1.5
Van 0.714 0.714 1
H3-Amp H3 0.056 0.056 1 3
Amp 5.724 11.450 2
H3-Rif H3 0.056 0.056 1 3
Rif 0.019 0.038 2
H3-Cip H3 0.056 0.056 1 1.5
Cip 1.510 0.755 0.5
  1. Van vancomycin, Amp ampicillin, Rif rifampicin, Cip ciprofloxacin, H1-Van, H2-Van, H3-Van H1, H2, H3 in combination with vancomycin, respectively, H1-Amp, H2-Amp, H3-Amp H1, H2, H3 in combination with ampicillin, respectively, H1-Rif, H2-Rif, H3-Rif H1, H2, H3 in combination with rifampicin, respectively, H1-Cip, H2-Cip, H3-Cip, H1, H2, H3 in combination with ciprofloxacin, respectively, MIC a the MIC of drug alone, MIC c the MIC of the most effective combination