AMB Express

Table 3 The PAE test for H1, H2, H3 against S. aureus

From: Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus

Strain	PAE (h)^a
Strain	V-2MIC	N-2MIC	H1-MIC	H1-2MIC	H2-MIC	H2-2MIC	H3-MIC	H3-2MIC
S. aureus ATCC43300	1.72 ± 0.11	1.43 ± 2.02	0.90 ± 0.04	2.94 ± 0.07	0.63 ± 0.13	1.75 ± 0.04	0.55 ± 0.13	1.55 ± 0.07

V-2MIC vancomycin at 2 × MIC, N-2MIC NZ2114 at 2 × MIC, H1-MIC, H1-2MIC, H2-MIC, H2-2MIC, H3-MIC, H3-2MIC H1, H2, H3 at 1 × , 2 × MIC, respectively
^aIn vitro observation values are the mean ± SD, n = 3

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