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Table 3 The PAE test for H1, H2, H3 against S. aureus

From: Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus

Strain PAE (h)a
V-2MIC N-2MIC H1-MIC H1-2MIC H2-MIC H2-2MIC H3-MIC H3-2MIC
S. aureus ATCC43300 1.72 ± 0.11 1.43 ± 2.02 0.90 ± 0.04 2.94 ± 0.07 0.63 ± 0.13 1.75 ± 0.04 0.55 ± 0.13 1.55 ± 0.07
  1. V-2MIC vancomycin at 2 × MIC, N-2MIC NZ2114 at 2 × MIC, H1-MIC, H1-2MIC, H2-MIC, H2-2MIC, H3-MIC, H3-2MIC H1, H2, H3 at 1 × , 2 × MIC, respectively
  2. aIn vitro observation values are the mean ± SD, n = 3