AMB Express

Table 2 MIC assays of H1, H2, H3, H6, H8, NZ2114, and vancomycin against G⁺ and G⁻ pathogens

From: Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus

Strains	MIC (μM)
Strains	H1	H2	H3	H6	H8	NZ	Van
Gram-positive bacteria
S. aureus ATCC25923	0.014	0.028	0.014	0.028	0.028	0.028^a	0.172
S. aureus ATCC43300	0.057	0.114	0.057	0.114	0.454	0.909^a	0.714
S. aureus ATCC6538	0.057	0.057	0.114	0.114	0.227	0.114^a	1.428
S. suis CVCC3309	0.014	0.028	0.014	0.028	0.028	0.028	0.172^b
S. suis CVCC3928	0.007	0.014	0.028	0.014	0.057	0.028	0.172^b
S. suis CVCC606	0.007	0.028	0.028	0.014	0.028	0.028	0.172^b
S. pneumoniae CVCC1.8722	0.227	0.227	0.454	0.454	1.818	0.454	NT
S. pneumoniae CVCC2350	0.227	0.227	0.227	0.454	1.818	0.909	NT
Gram-negative bacteria
S. enteritidis CMCC50336	>7.273	>7.273	>7.273	>7.273	>7.273	>7.273	NT
S. typhimurium ATCC14028	>7.273	>7.273	>7.273	>7.273	>7.273	>7.273	NT
S. choleraesuis CVCC503	>7.273	>7.273	>7.273	>7.273	>7.273	>7.273	NT
S. pullorum CVCC1789	>7.273	>7.273	>7.273	>7.273	>7.273	>7.273	NT
E. coli CVCC195	>7.273	>7.273	>7.273	>7.273	>7.273	>7.273	NT
E. coli CICC21530	>7.273	>7.273	>7.273	>7.273	>7.273	>7.273	NT

NZ NZ2114, Van vancomycin, NT no test
^aThe data are from previous results (Zhang et al. 2014)
^bThe data are from previous results (Jiao et al. 2015)

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