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Table 2 MIC assays of H1, H2, H3, H6, H8, NZ2114, and vancomycin against G+ and G pathogens

From: Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus

Strains MIC (μM)
H1 H2 H3 H6 H8 NZ Van
Gram-positive bacteria
 S. aureus ATCC25923 0.014 0.028 0.014 0.028 0.028 0.028a 0.172
 S. aureus ATCC43300 0.057 0.114 0.057 0.114 0.454 0.909a 0.714
 S. aureus ATCC6538 0.057 0.057 0.114 0.114 0.227 0.114a 1.428
 S. suis CVCC3309 0.014 0.028 0.014 0.028 0.028 0.028 0.172b
 S. suis CVCC3928 0.007 0.014 0.028 0.014 0.057 0.028 0.172b
 S. suis CVCC606 0.007 0.028 0.028 0.014 0.028 0.028 0.172b
 S. pneumoniae CVCC1.8722 0.227 0.227 0.454 0.454 1.818 0.454 NT
 S. pneumoniae CVCC2350 0.227 0.227 0.227 0.454 1.818 0.909 NT
Gram-negative bacteria
 S. enteritidis CMCC50336 >7.273 >7.273 >7.273 >7.273 >7.273 >7.273 NT
 S. typhimurium ATCC14028 >7.273 >7.273 >7.273 >7.273 >7.273 >7.273 NT
 S. choleraesuis CVCC503 >7.273 >7.273 >7.273 >7.273 >7.273 >7.273 NT
 S. pullorum CVCC1789 >7.273 >7.273 >7.273 >7.273 >7.273 >7.273 NT
 E. coli CVCC195 >7.273 >7.273 >7.273 >7.273 >7.273 >7.273 NT
 E. coli CICC21530 >7.273 >7.273 >7.273 >7.273 >7.273 >7.273 NT
  1. NZ NZ2114, Van vancomycin, NT no test
  2. aThe data are from previous results (Zhang et al. 2014)
  3. bThe data are from previous results (Jiao et al. 2015)