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Table 1 Antifouling activity of 55 compounds against the cyprids of barnacle B. amphitrite (EC50 in μM), toxicity (LC50 in μM) and LC50/EC50 ratios

From: Antifouling phenyl ethers and other compounds from the invertebrates and their symbiotic fungi collected from the South China Sea

Compounds EC50 LC50 LC50/EC50
Diorcinol (1) 32.6 >217 >6.67
Cordyol C (2) 57.3 >203 >3.54
4-Methoxyacyl-diorcinol (3) 7.43 >174 >23.4
Cordyol E (4) 31.0 >205 >6.61
3,3′-O-dimethylviolaceol-I (5) 18.4 >172 >9.35
Cordyol D (6) 18.2 >164 >9.01
3-O-propyl-diorcinol (7) 9.82 112 11.4
3-O-pentyl-diorcinol (8) 27.9 >167 >5.99
3-O-acetyl-diorcinol (9) 3.05 64.3 21.1
3-O-benzoyl-diorcinol (10) 12.6 >150 >11.9
3,3′-O-diacetyl-diorcinol (11) 2.23 49.4 22.2
3,3′-O-dipentyl-diorcinol (12) 12.2 >135 >11.1
2,4,6,2′,4′,6′-Hexabromo-diorcinol (13) 0.71 22.0 31.0
2,6,2′,4′,6′-Pentabromo-4-methoxycarbonyl-diorcinol (14) 1.17 29.3 25.0
3-O-p-Bromobenzoyl-diorcinol (15) 2.42 60.5 25.0
1-Formylguaiazulene (16) 42.0 221 5.26
1-Formyl-4-methyl-7-isopropylazulene (17) 14.7 >236 >16.1
Ochracenoid A (18) 83.3 208 2.5
3,8-Dimethyl-5-isopropyl-6-formylindenone (19) >110 >219 UD
Ochracenoid B (20) >110 >219 UD
Ketolactone (21) >104 >208 UD
Furospongin-1 (22) 6.06 153 25.2
3β,6α,11-Trihydroxy-24-nor-9,11-seco-5α-cholest-7-en-9-one (23) 10.7 59.5 5.56
(24R)-and(24S)-3β,6α,11-Trihydroxy-methyl-9,11-seco-5α-cholest-7-en-9-one (24) >55.8 >112 UD
(22E)-3β,6α,11-Trihydroxy-24-nor-9,11-seco-5α-cholesta-7,22-dien-9-one (25) 29.9 59.8 2.00
3β,6α,11-Trihydroxy-9,11-seco-5α-cholest-7-en-9-one (26) 28.6 57.6 2.01
3β,6α,11-Trihydroxy-9,11-seco-5α-cholesta-7,24(28)-dien-9-one (27) >56.1 >56.1 UD
(22E,24R)-3β,6α,11-trihydroxy-24-Methyl-9,11-seco-5α-cholesta-7,22-dien-9-one (28) 44.8 >56.1 >1.25
(22E)-3β,6α,11-Trihydroxy-9,11-seco-5α-cholesta-7,22-dien-9-one (29)
Subergorgol I (29)
14.7 57.9 3.94
(22E)-6,11-Diacetoxy-3-hydroxy-9,11-seco-5α-cholesta-7,22-dien-9-one (30) 6.01 96.8 16.1
(22E)-3,6,11-Triacetoxy-9,11-seco-5α-cholesta-7,22-dien-9-one (31) 12.1 96.8 8.00
Averufin (32) 9.27 >136 >14.7
8-O-methylnidurufin (33) 14.4 >126 >8.75
Nidurufin (34) >65.1 >130 UD
Questinol (35) >83.3 >167 UD
ω-Hydroxyrubrocristin (36) >79.1 >158 UD
Asperinine A (37) 30.5 >87.7 >2.88
Asperinine B (38) 39.5 >87.7 >2.22
Rhodoptilometrin (39) 11.9 159 13.4
Variecolortide C (40) >82.9 >82.9 UD
7-O-methylvariecolortide A (41) >74.5 >74.5 UD
Variecolortide B (42) >84.9 >84.9 UD
Dihydroxyisoechinulin A (43) >118 >118 UD
Echinulin (44) >54.2 >108 UD
Neoechinulin (45) 46.4 >155 >3.34
Aspochalasin K (46) 17.3 >115 >6.65
Aspochalasin E (47) 32.2 >119 >3.70
Kipukasin H (48) >61.3 >123 UD
Kipukasin E (49) >59.2 >59.2 UD
Kipukasin D (50) >59.2 >59.2 UD
Diacetylkipukasin E (51) 44.5 >98.8 >2.22
Diacetylkipukasin D (52) >49.4 >98.8 UD
Penilumamide (53) >96.9 >96.9 UD
Penilumamide D (54) >58.8 >58.8 UD
Asperpeptide A (55) >46.6 >46.6 UD
Sea-Nine 211™ 4.36 88.7 20.3
  1. UD undetectable