|
parameter
|
NASBA-ELISA ora RT-PCR
|
NASBA-ELISA andb RT-PCR
|
NASBA-ELISA or GM-ELISA
|
NASBA-ELISA and GM-ELISA
|
RT-PCR or GM-ELISA
|
RT-PCR and GM-ELISA
|
|---|
|
Sensitivity
|
97.22 (85.47–99.93)
|
55.56 (38.10–72.06)
|
83.33 (67.19–93.63)
|
55.56 (38.10–72.06)
|
77.78 (60.85–89.88)
|
52.78 (35.49–69.59)
|
|
Specificity
|
68.00 (53.30–80.48)
|
94.00 (83.45–98.75)
|
62.00 (47.17–75.35)
|
100 (92.89–100)
|
66.00 (51.23–78.79)
|
98.00 (89.35–99.95)
|
|
Positive likelihood ratio
|
3.04 (2.02–4.57)
|
9.26 (2.98–28.82)
|
2.19 (1.50–3.22)
|
Infinity
|
2.29 (1.50–3.49)
|
26.39 (3.70–188.24)
|
|
Negative likelihood ratio
|
0.04 (0.01–0.28)
|
0.47 (0.33–0.69)
|
0.27 (0.13–0.58)
|
0.44 (0.31–0.64)
|
0.34 (0.18–0.64)
|
0.48 (0.34–0.68)
|
|
PPV [% (95 % CI)]
|
68.63 (54.11–80.89)
|
86.96 (66.41–97.22)
|
61.22 (46.24–74.80)
|
100 (83.16–100)
|
62.22 (46.54–76.23)
|
95.00 (75.13–99.87)
|
|
NPV [% (95 % CI)]
|
97.14 (85.08–99.93)
|
74.60 (62.06–84.73)
|
83.78 (67.99–93.81)
|
75.76 (63.64–85.46)
|
80.49 (65.13–91.18)
|
74.24 (61.99–84.22)
|
|
Youden index
|
0.652
|
0.496
|
0.453
|
0.556
|
0.438
|
0.508
|
- Combined analysis for both proven IA (n = 9) and probable IA (n = 27)
- Best performance values are highlighted in italics
-
a “or” indicates that at least one of the assays is required to be positive
-
b “and” indicates that both assays are required to be positive before a patient is considered positive
