Table 3 Performance parameters for GM ELISA, Aspergillus RT-PCR, and Aspergillus NASBA-ELISA when testing cases of proven/probable IA

Sensitivity [% (95 % CI)]

80.56 (63.98–91.81)

72.22 (54.81–85.80)

58.33 (40.76–74.49)*

Specificity [% (95 % CI)]

80.00 (66.28–89.97)

84.00 (70.89–92.83)

82.00 (68.56–91.42)

Positive likelihood ratio

4.03 (2.26–7.17)

4.51 (2.32–8.79)

3.24 (1.69–6.23)

Negative likelihood ratio

0.24 (0.12–0.48)

0.33 (0.19–0.57)

0.51 (0.34–0.76)

PPV [% (95 % CI)]

74.36 (57.87–86.96)

76.47 (58.83–89.25)

70.00 (50.60–85.27)

NPV [% (95 % CI)]

85.11 (71.69–93.80)

80.77 (67.47–90.37)

73.21 (59.70–84.17)

Youden index

0.61

0.56

0.40

κ statistic

0.60

0.57

0.41